J Herbmed Pharmacol. 2013;2(1):5-8.
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Original Article

Reversal effect of Achillea millefolium extract on ileum contractions

Mehrnoosh Sedighi 1, Hamid Nasri 2, Mahmoud Rafieian-kopaei 1 * , Seifollah Mortazaei 1

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding author: Prof. Mahmoud Rafieian-kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. Email: rafieian@skums.ac.ir

Abstract

Introduction: Traditionally Achillea millefolium L. has been used to treat gastrointestinal disorders. In this study the hydroalcoholic extract of A. millefolium was evaluated on ileum contractions of Wistar rats.

Materials and Methods: In this experimental study 32 male Wistar rats were designated into 4 equal groups, including: acetyl choline, KCl, extract plus acetyl choline and the group which received extract plus KCl. The isotonic contractions of ileum (induced by 60 mM KCl or 1 μM acetyl choline) in tyrode solution were recorded, under 1 gr tension. Then, the effects of normal saline or extract (1%) were evaluated. The percentage changes were calculated and compared in different groups using ANOWA and Tukey tests.

Results: The mean of ileum contractions in acetyl choline and KCl groups were 18.83±4.91 and 18.31±11.12 (p=0.5). The percentage of contraction relieve in extract plus acetyl choline group was 53.16±12.06 and in extract plus KCl group was 62.96±11.08 (p=0.4). The contractions in extract groups were significantly less than acetyl choline or KCl groups (p<0.05).

Conclusion: The results indicate that Achillea millefolium extract inhibits ileum contractions. Therefore, it might be used in patients to reduce ileum spasms.

Implication for health policy/practice/research/medical education:

Achillea millefolium possesses relaxation effect on ileum contraction activity and might be used in gastrointestinal spasms.

Please cite this paper as: Sedighi M, Nasri H, Rafieian-kopaei M, Mortazaei S. Reversal effect of Achillea millefolium extract on ileum contractions. J Herbmed Pharmacol. 2013; 2(1): 5-8.

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First published online: 01 Jun 2013
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