J Herbmed Pharmacol. 2018;7(1):8-12.
doi: 10.15171/jhp.2018.02

Scopus id: 85039849611
  Abstract View: 800
  PDF Download: 748

Original Article

Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats

Leila Safaeian 1 * ORCiD, Bahar Baniahmad 2, Zahra Esfandiari 3, Sayed Ali Alavi 4

1 Department of Research and Development, Vice Chancellery for Food and Drug, Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Research and Development, Vice-Chancellery for Food and Drug, Isfahan University of Medical Sciences, Isfahan, Iran
4 Hakiman Shargh Investigative Corporation, Isfahan Science and Technology Town, Isfahan, Iran

Abstract

Introduction: Portulaca oleracea is used as a nutritional and medicinal plant. The aim of this study was to assess the effect of hydroalcoholic extract of P. oleracea seeds in dexamethasone -induced hypertension in rats.Methods: For induction of hypertension, dexamethasone (30 μg/kg/d, subcutaneously) was administered for 14 days. Animals received P. oleracea extract as a pretreatment at various doses of 100, 200 and 400 mg/kg/d orally from 4 days before dexamethasone administration and during the test period. Systolic blood pressure (SBP) and heart rate were measured using tail-cuff method. The weight of thymus gland was estimated as a marker of glucocorticoid activity.Results: Dexamethasone injection significantly increased SBP (P < 0.001) while decreased the body and thymus weights (P < 0.05 and P < 0.001, respectively). Oral administration of P. oleracea could not prevent rising in SBP and decreasing in thymus weight. It also increased heart rate in hypertensive rats at the dose of 400 mg/kg/d (P < 0.05).Conclusion: The results of this study revealed that hydroalcoholic extract of P. oleracea seeds aggregates hypertension in dexamethasone-induced hypertensive rats. Hence, it should be used with caution in hypertensive patients receiving glucocorticoids.
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Submitted: 10 Oct 2017
Revised: 08 Nov 2017
Accepted: 29 Dec 2017
First published online: 29 Dec 2017
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