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J Herbmed Pharmacol. 2016;5(1): 29-32.
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Original Article

Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat

Ali Mohammadian 1, Shirin Moradkhani 2, Sara Ataei 3, Tavakol Heidary Shayesteh 4, Mahsa Sedaghat 3, Nejat Kheiripour 1, 5, Akram Ranjbar 4*

1 Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pharmacogenosy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran

Abstract

Introduction: Artemisia absinthium L. (AA) is a large, diverse genus of the family Asteraceae. AAhas long been used as customary herbal medicine in world for the treatment of gastric pain, cardiacstimulation, improvement of memory and for the restoration of declined mental function. The aimof present study was to evaluate the hepatoprotective effects of AA on some factors ref lecting thedevelopment of oxidative toxic stress in plasma.Methods: Twenty male rats were equally divided in to 4 groups (5 rats each). Group I actedas control (received normal salin). Treatment groups were II, III and IV which were givenArtemisia 10, 50 and 100 mg/kg/day respectively only by gavage for 24 hours. After treatment,blood specimens were collected. Liver enzymes such as aspartate aminotransferase (AST) andalanine aminotransferase (ALT) with total antioxidant power (TAP) and total thiol groups (TTG)concentrations were measured.Results: Levels of ALT, AST and TTG were decreased in the group II compared to the control(group I). ALT and AST in 50 mg/kg group was observed compared with control group. Also, TTGincreased in Artemisia 50 mg/kg group compared to control group.Conclusion: Results suggests that alcoholic extract of Artemisia can ameliorate liver toxicity inrats through reducing the serum levels of ALT, AST, and oxidative damage.
Keywords: Artemisia, Oxidative toxic stress, ALT, AST, Rat
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Revision: 05 Oct 2015
ePublished: 06 Dec 2015
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