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J Herbmed Pharmacol. 2016;5(3): 112-115.
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Original Article

Antibacterial activity and ciprofloxacin-potentiation property of Berberis vulgaris asperma stem extracts on pathogenic bacteria

Azizollah Ebrahimi 1*, Mohadaseh Chavoshpour 2, Mohamad Reza Mahzoonieh 1, Sharareh Lotfalian 1

1 Department of Pathobiology, School of Veterinary Science, Shahrekord University, Shahrekord, Iran
2 Msc Student of Bacteriology, Department of Pathobiology, Veterinary College, Shahrekord University, Iran

Abstract

Introduction: This study was planned to search the antibacterial activities of the ethanol and Chloroform extracts of Berberis vulgaris asperma stem and their synergistic effects with ciprofloxacin against some gram-negative pathogenic bacteria.Methods: Broth micro-dilution method was used for determination of minimum inhibitory concentrations (MICs) of the extracts alone or in association with ciprofloxacin and Phenylalanine-Arginine β-Naphtylamide (PAβN) as a positive control and efflux pumps inhibitor (EPI).Results: MIC determination indicated that the extracts from Berberis vulgaris asperma stem were able to inhibit the growth of all the studied bacteria within a concentration range of 3900 to 37500 μg/mL. Synergistic effects were noted between the extracts from Berberis vulgaris asperma stem extracts and ciprofloxacin on all tested bacteria except Acinetobacter bummani.Conclusion: Berberis vulgaris asperma stem extracts act as an antibacterial agent and potentiate ciprofloxacin effects on examined pathogenic bacteria.
Keywords: Antibacterial activities, Berberis vulgaris asperma, Gram-negative bacteria
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Revision: 04 Mar 2016
ePublished: 29 Jun 2016
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