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J Herbmed Pharmacol. 2013;2: 29-33.
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Original Article

The effect of silymarin on liver injury induced by Thioacetamide in rats

Najmeh Kabiri 1, Mahboobeh Ahangar-Darabi 2, Mahbubeh Setorki 3, Mahmoud Rafieian-kopaei 4*

1 MSc, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran
3 Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
4 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: *Corresponding author: Mahmoud Rafieian-kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran., Email: rafieian@yahoo.com

Abstract

Introduction: In this study the protective effects of Silymarin was investigated against thioacetamide (TAA) induced hepatotoxicity in rat.

Methods: In an experimental study 24 male Wistar rats were designated in four equal groups as follows: Control group, the group treated with thioacetamide (TAA), Silymarin (400 mg/kg for 3 weeks) + TAA (400 mg/kg), TAA (400 mg/kg) + Silymarin (400 mg/kg for 3 weeks). The levels of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) lactate dehydrogenase (LDH) and total bilirubin were measured to assess the hepatotoxicity and hepatoprotection.

Results: TAA significantly increased AST, ALT, ALP, LDH and bilirubin. Treatment by Silymarin caused a significant reduction in serum levels of AST, ALT, ALP, LDH and bilirubin contents.

Conclusion: The results indicate a protective effect for Silymarin against thioacetamide induced hepatotoxicity which might be due to its ability to block the bioactivity of thioacetamide.

Keywords: Hepatoprotection, Thioacetamide, Silymarin, Rat

Implication for health policy/practice/research/medical education:

Silymarin has hepatoprotective activity against thioacetamide induced hepatotoxicity and its usage might be useful in patient who need to protect their body against hepatotoxic agents.

Please cite this paper as: Kabiri N, Ahangar-Darabi M, Setorki M, Rafieian-kopaei M. The effect of silymarin on liver injury induced by Thioacetamide in rats. J Herbmed Pharmacol. 2013; 2(2): 29-33.

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ePublished: 01 Dec 2013
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