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J Herbmed Pharmacol. 2013;2: 45-48.
  Abstract View: 2442
  PDF Download: 2008

Original Article

Does Royal jelly affect tumor cells?

Maryam Shirzad, Rahimeh Kordyazdi, Najmeh Shahinfard, Morteza Nikokar*

1 Medical Plant Research Center, Shahrekord University of medical sciences, shahrekord , Iran
*Corresponding Author: *Corresponding author: Morteza Nikokar, Medical Plant Research Center, Shahrekord University of medical sciences, shahrekord , Iran., Email: nikokar@yahoo.com

Abstract

Introduction: Royal jelly is a substance that appears to be effective on immune system and it appears to be effective on both prevention and growth of cancer cells. In this study, we aimed to carry out a research to investigate the effect of royal jelly on the growth of WEHI-164 fibrosarcoma cell in syngenic Balb/c mice.

Methods: In an experimental study, 28 male Balb/c mice were designated into four equal groups. The mice were subcutaneously injected with 5x105 WEHI-164 tumor cells on the day zero in the chest area of the animal. Animals in groups 1 to 4 were orally given 100, 200, 300 mg/kg of royal jelly or vehicle, respectively. In every individual mouse, the tumour size was measured every 2 days from day 5 (days 5, 7, 9, 11, 13, 15 and 17). Data were statistically analyzed using Kruskal-Wallis and Mann Whitney-U tests.

Result: Our results showed that the mean size of tumor in case group was significantly smaller than the control group in days 11, 13, 15 and 17 (P<0.05). No metastasis was seen in test and control groups.

Conclusion: With emphasize on antitumor effect of royal jelly, it seems that royal jelly has important role in control and regression of fibrosarcoma cells. Since royal jelly showed a delayed effect in control of fibrosarcoma, we suggest that royal jelly be used at least 10 days before tumor inoculation

Keywords: Balb/c mice, Fibrosarcoma, Royal jelly

Implication for health policy/practice/research/medical education:

Royal jelly demonstrated an important activity in control and regression of fibrosarcoma cells in preclinical study. Therefore, clinical studies are recommended to evaluate its beneficial effects in prevention and treatment of different cancer types.

Please cite this paper as: Shirzad M, Kordyazdi R, Shahinfard N, Nikokar M . Does Royal jelly affect tumor cells? J Herbmed Plarmacol. 2013; 2(2): 45-48.

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ePublished: 01 Dec 2013
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