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J Herbmed Pharmacol. 2015;4: 10-14.
  Abstract View: 1989
  PDF Download: 1611

Original Article

Effect of Kelussia odoratissima Mozaff essential oil on promastigot form of Leishmania major (in vitro)

Khodadad Pirali Kheirabadi 1*, Siavash Saei Dehkordi 2, Parviz Kheibari 3

1 Department of pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
2 Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
3 Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
*Corresponding Author: *Corresponding author: Khodadad Pirali Kheirabadi, Department of Pathobiology, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran. Tel: +98-3814424427, , Email: khpirali@yahoo.com

Abstract

Introduction: Leishmaniasis is a zoonotic disease caused by a protozoan of the genus Leishmania. In this study, the effects of  Kelussia odoratissima Mozaff essential oil on the promastigot form of Leishmania major were studied.

Methods: In this study, the effects of Kelussia odoratissima Mozaff essential oil on the promastigot form of Leishmania major were assessed by calculating the average number of surviving promastigots after exposure to different concentrations of essential oil, relative to the control Glucantime, at different time intervals. To achieve this, various essential oil concentrations (7.5 μl, 15 μl, 25 μl, 35.25 μl, 50 μl) were added to parasites. Different groups in this study were kept in a 26°C incubator under identical conditions. 24, 48 and 72 hours after incubation, living promastigots were counted.

Results: The effect of the essential oil of Kelussia odoratissima Mozaff differed from the negative and positive controls and depended on the concentration: higher concentrations (35.25 μl, 50 μl) had a stronger effect on promastigots, causing total mortality.

Conclusion: This study showed that Kelussia odoratissima Mozaff essential oil had effects on promastigot form of Leishmania major. So it might be possible to use the essential oil of Kelussia odoratissima instead of chemical drugs.

Keywords: Essential oil, In vitro, Kelussia odoratissima, Leishmaniasis, Promastigot form

Implication for health policy/practice/research/medical education:

It is possible to use the essential oil of Kelussia odoratissima instead of chemical drugs. The use of any concentration of essential oil of Kelussia odoratissima controlled L. major more effectively by increasing in essential oil concentration. Future research would assess the effect of this essential oil on the amastigote form of L. major.

Please cite this paper as: Pirali Kheirabadi K, Saei Dehkordi S, Kheibari P. Effect of Kelussia odoratissima Mozaff essential oil on promastigot form of Leishmania major (in vitro). J Herbmed Pharmacol 2015; 4(1): 10-14.

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