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J Herbmed Pharmacol. 2016;5(1): 1-6.
  Abstract View: 1176
  PDF Download: 576

Original Article

GABA mediated response of aqueous, ethanol and ethyl acetate extracts of Dicranopteris linearis leaf in Swiss Albino mice

Mohammad Mustakim Billah 1*, Kashfia Nawrin 1, Kh Tanvir Ahmed 2, Mohammed Sahek Ullah Jabed 1, Md. Nasidul Islam 3, Md. Main Uddin 4

1 Department of Pharmaceutical Sciences, North South University, Bangladesh
2 Mylan School of Pharmacy, Duquesne University, USA
3 Department of Pharmacy, East West University, Bangladesh
4 Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Bangladesh
Department of Pharmaceutical Sciences, North South University, Bangladesh mustakimbillah@hotmail.com

Abstract

Introduction: The objective of the study was to assess the potential of the leaf of Dicranopteris linearis in altering the CNS functions with three different extracts; aqueous, ethanol and ethyl acetate.Methods: To evaluate and compare the activities Morris maze, elevated plus maze (EPM),open field, hole cross and head dip tests were performed and many behavioral parameters wereobserved. The forced swim in Morris water maze analyzed the depression of rodents in termsof inability to self-rescue. Alongside, hole cross and open field tests assessed the inhibition oflocomotor activities. Moreover, EPM test screened the anxiolytic potential while the head dippinghole board test supported the previous experiments by evaluating both sedative, depressive andanxiolytic potentials of the extracts.Results: The results showed that the ethanol extract significantly suppressed CNS activity byreducing number of locomotor activities and increasing the stability phase (in EPM and Morrismaze) supporting mild sedation, depression and anxiolysis. Furthermore, the ethyl acetate extractalso possessed moderate to high potential in reducing locomotor activities depending on gradientdoses. Results were compared with control group and found statistically significant.Conclusion: As this plant mimic the activity of a gamma-aminobutyric acid (GABA) agonist, itcan be concluded that the plant may have GABA mediated involvement in central nervous system.However, the responsible compounds for these activities are yet to be investigated and this maypotentiate a new source of drug development.
Keywords: Dicranopteris linearis, Maze test, Hole cross, Open field, Head dipping
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Revision: 07 Sep 2015
ePublished: 06 Dec 2015
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