J Herbmed Pharmacol. 2018;7(1):13-17.
doi: 10.15171/jhp.2018.03

Scopus id: 85039872466
  Abstract View: 943
  PDF Download: 697

Original Article

Protective effect of Solanum tuberosum against the breakdown of red blood cells: an experimental study in burn injury model

Emin Zumrutdal 1 * ORCiD, Tuna Bilecik 2, Basak Unver Koluman 3, Umit Turan 2, Kenan Daglıoglu 4, Murat Gunduz 5, Mustafa Gencoglu 6, Sadik Dincer 6, Suleyman Cetinkunar 2

1 Department of Surgery, EPC Hospital, Adana, Turkey
2 Department of Surgery,Adana Numune Research and Training Hospital, Adana, Turkey
3 Department of Haematology, Adana Numune Research and Training Hospital, Adana, Turkey
4 Animal Research Center, University of Cukurova, Adana, Turkey
5 Department of anesthesia and reanimation University of Cukurova, Adana, Turkey
6 Department of biology, Science and letter faculty, University of Cukurova, Adana Turkey

Abstract

Introduction: Anemia is known to be an important problem in burn injury. We aimed to investigate the protective effect of Solanum tuberosum (potatoes), against abnormal breakdown of erythrocytes in burn injury.Methods: Ninety-six male (9 to 10 weeks old) Swiss Albino mice (34–40 g) were included into the study, which consisted of two phases: dose optimization phase (n = 48) and study phase (n = 48). Half of the mice were given S. tuberosum juice (study group) and the other half drinking water (control group). The optimal dosage causing minimum decline in hematocrit was as follows: 1.6 mL/kg at 0 h, 0.8 mL/kg at 24 hours, and 0.8 mL/kg at 36 hours of burn injury. The burn injury was induced with a solid 10-mm aluminum bar heated in boiling water.Results: The decrease in hematocrit level was significantly lower in the study group than the control group at 24 and 48 hours (P = 0.05 and P = 0.023, respectively). The increase in anisocytosis, a hemolytic anemia sign, was also significantly lower in the study group than the control group at 48 hours (P = 0.021). There was no significant difference between groups in terms of clotting time or the bleeding time.Conclusion: In burn injury, S. tuberosum may be beneficial against anemia and it may reduce the need for red blood cell transfusion.
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Submitted: 08 May 2017
Revised: 15 Jun 2017
Accepted: 29 Dec 2017
First published online: 29 Dec 2017
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