J Herbmed Pharmacol. 2019;8(2):160-162.
doi: 10.15171/jhp.2019.25
  Abstract View: 268
  PDF Download: 316

Short Communication

Genotoxic potential of selected medicinal plant extracts in human whole blood cultures

Karina Harutyunyan 1 ORCiD, Karine Balayan 2, Gohar Tadevosyan 3, Manush Hayrapetyan 1, Ruzanna Musayelyan 1, Ruzanna Grigoryan 3, Lusine Khondkaryan 3, Natalya Sarkisyan 3, Nelly Babayan 3, 4 * ORCiD

1 Artsakh Scientific Centre, Stepanakert, RA
2 Department of Biology, Artsakh State University, Stepanakert, RA
3 Group of Cell Technologies, Institute of Molecular Biology, National Academy of Sciences, Yerevan, RA
4 Department of Genetics and Cytology, Yerevan State University, Yerevan, RA

Abstract

Introduction: Many plant-derived products despite wide usage are not scientifically evaluated for their safety and efficacy. Therefore, in the present study, we aimed to evaluate the cytotoxic and genotoxic activities of Polygonum aviculare L., Equisetum arvense L., Plantago lanceolata L. and Artemisia absinthium L. ethanolic extracts in human white blood cells. Methods: Cell viability was assayed by trypan blue exclusion method, while the genotoxicity was tested by cytokinesis-block micronucleus (CBMN) assay upon cells stimulation with noncytotoxic concentrations of the plant extracts. Results: None of the plant extracts showed high cytotoxic activity. At the same time, only extract of P. lanceolata did not present any mutagenic activity, while E. arvense, P. aviculare and A. absinthium were clearly genotoxic. Conclusion: Caution is advice in the case of long-term use of E. arvense, P. aviculare and A. absinthium herbal medicines by population.
Introduction: Many plant-derived products despite wide usage are not scientifically evaluated for their safety and efficacy. Therefore, in the present study, we aimed to evaluate the cytotoxic and genotoxic activities of Polygonum aviculare L., Equisetum arvense L., Plantago lanceolata L. and Artemisia absinthium L. ethanolic extracts in human white blood cells. Methods: Cell viability was assayed by trypan blue exclusion method, while the genotoxicity was tested by cytokinesis-block micronucleus (CBMN) assay upon cells stimulation with non-cytotoxic concentrations of the plant extracts. Results: None of the plant extracts showed high cytotoxic activity. At the same time, only extract of P. lanceolata did not present any mutagenic activity, while E. arvense, P. aviculare and A. absinthium were clearly genotoxic. Conclusion: Caution is advice in the case of long-term use of E. arvense, P. aviculare and A. absinthium herbal medicines by population.
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Submitted: 16 Aug 2018
Revised: 08 Nov 2018
Accepted: 16 Nov 2018
First published online: 25 Feb 2019
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