Logo-jhp
J Herbmed Pharmacol. 2022;11: 107-113.
doi: 10.34172/jhp.2022.12
  Abstract View: 363
  PDF Download: 205

Original Article

Preliminary phytochemical screening, acute toxicity and effect of Albuca amoena extracts on the central nervous system

Rajaâ Zakhour 1 ORCID logo, Meryem El Jemly 1 ORCID logo, Otman El Guourrami 2 ORCID logo, Rachid Nejjari 3 ORCID logo, Abdelhakim Bouyahya 4* ORCID logo, Yahia Cherrah 1 ORCID logo, Katim Alaoui 1 ORCID logo

1 Laboratory of Pharmacodynamy and Toxicology, Research Team ERTP.PAM, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco
2 Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco
3 Laboratory of Pharmacognosy, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco
4 Laboratory of Human Pathologies Biology, Faculty of Sciences, Department of Biology, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco
*Corresponding Author: Email: boyahyaa-90@hotmail.fr

Abstract

Introduction: Albuca amoena is a Moroccan-Algerian endemic medicinal plant with various implications. The aim of this study is to identify phytochemical compounds of the plant, check its acute toxicity, and test its anti-depressive, anxiolytic, and analgesic effects on the central nervous system (CNS). Methods: The estimation of chemical compounds was carried out according to coloring and precipitation reactions. The Organization of Economic Cooperation and Development guidelines 423 and 402 made it possible to verify the acute toxicity of the plant orally and dermally. The sedative activity was performed according to 4 tests: rotarod, hole-board, traction, and chimney tests. The anti-depressive, anxiolytic, and analgesic effects were evaluated by forced swimming, light/dark, and writhing tests, respectively. Results: The phytochemical analysis showed that A. amoena contained a mixture of phytochemical compounds like terpenes, alkaloids, and polyphenols. According to the acute toxicity tests, the lethal dose of 50% (LD50) of A. amoena hydroalcoholic extract was between 300 and 2000 mg/kg orally and higher than 2000 mg/kg dermally. Moreover, the result of the behaviour tests of sedative and analgesic activities revealed that A. amoena hydroalcoholic extract exerted positive effects on the CNS. Conclusion: These results show the anti-depressive, anxiolytic, and analgesic effects of the bioactive substances present in A. amoena on the CNS and provide access to further investigations to highlight the main compounds of this plant and their mechanisms of actions.
Keywords: Albuca amoena, Phytochemical screening, Acute toxicity, Central nervous system, Sedative activity, Analgesic activitiy

Extracts of A. amoena showed remarkable anti-depressive, anxiolytic, and analgesic effects on CNS and did not reveal toxicity. A. amoena may have significant implications for the future development of anti-depressive, anxiolytic, and analgesic drugs targeting CNS-related pathologies.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 364

Your browser does not support the canvas element.


PDF Download: 205

Your browser does not support the canvas element.

Submitted: 02 May 2021
Revision: 21 Sep 2021
Accepted: 25 Sep 2021
ePublished: 29 Nov 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)