Logo-jhp
J Herbmed Pharmacol. 2021;10(4): 500-507.
doi: 10.34172/jhp.2021.57
  Abstract View: 151
  PDF Download: 116

Original Article

Neuroprotective effect of ethanolic leaf extract of Commiphora caudata (Wight & Arn) against lipopolysaccharide-induced neurotoxicity in Wistar rats

Ponmalai Srinivasan 1 ORCID logo, Balasubramanian Arul 1 ORCID logo, Ramalingam Kothai 1* ORCID logo

1 Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636008, Tamilnadu, India

Abstract

Introduction: Commiphora caudata contains various essential phytoconstituents and is a potential medicinal plant used traditionally to treat various ailments such as neurodegenerative diseases. The present study aimed to evaluate the neuroprotective effect of ethanolic leaf extract of Commiphora caudata against the lipopolysaccharides (LPS) induced behavioral changes in rats. Methods: The in-vitro antioxidant potential was evaluated by 1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assay methods. For in-vivo studies, the animals were pre-treated with ethanolic leaf extract of Commiphora caudata (EECC) at 200 and 400 mg/kg of b.w for 30 days, and neurotoxicity was induced with a single intraperitoneal injection of LPS 1 mg/kg, b.w on day 31. The neurotoxicity was evaluated with a chain of behavioral tests such as the Morris water maze test, radial arm maze, and choice reaction time (CRT) tests. At the end of the study, rats were sacrificed, the brain hippocampal region was removed, and the levels of acetylcholinesterase, nitric oxide, and protein were measured. Results: The IC50 value in the DPPH method was 71.58 ± 15.62 μg, and the total antioxidant activity of EECC was found to be 742.33 ± 14.57 μmol Fe (II)/g extract. In behavioral tests, animals treated with EECC at 200 and 400 mg/kg showed a neuroprotective effect in the Morris water maze test, an 8-arm radial maze test, and in the CRT test. Both doses reduced acetylcholinesterase, nitric oxide, and protein levels (P < 0.001), respectively. Conclusion: The present study results showed the promising neuroprotective effects of ethanolic extract of leaves of Commiphora caudata and its action against the LPS-induced cognitive impairment in rats.
Keywords: Commiphora caudata, Lipopolysaccharide, Behavioural studies, Neuroprotective effect

Implication for health policy/practice/research/medical education:

This research work showed the promising neuroprotective effects of ethanolic leaf extract of Commiphora caudate against the LPS-induced neurotoxicity in rats. Thus, this plant might be considered a candidate for the isolation of compounds which leads to identifying the novel lead compounds for the development of drugs against neurodegenerative disorders.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 151

Your browser does not support the canvas element.


PDF Download: 116

Your browser does not support the canvas element.

Submitted: 06 Jul 2021
Revision: 07 Sep 2021
Accepted: 09 Sep 2021
ePublished: 04 Oct 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)