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J Herbmed Pharmacol. 2022;11: 10-19.
doi: 10.34172/jhp.2022.02
  Abstract View: 431
  PDF Download: 295

Review

An overview of the chemistry and anticancer properties of rosemary extract and its diterpenes

Eric Wei Chiang Chan 1* ORCID logo, Siu Kuin Wong 2 ORCID logo, Hung Tuck Chan 3 ORCID logo

1 Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
2 School of Foundation Studies, Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia
3 Secretariat of International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan
*Corresponding Author: Email: erchan@yahoo.com

Abstract

Rosemary (Rosmarinus officinalis L.), a culinary herb of the family Lamiaceae, has promising anticancer activity. This overview has updated the current knowledge on the chemistry and anticancer properties of rosemary extract, carnosic acid, carnosol, and rosmanol, focusing on colon and prostate cancer cells since they are the most susceptible. The information was procured from Google, Google Scholar, PubMed, PubMed Central, Science Direct, J-Stage, and PubChem. Phenolic compounds isolated from the aerial parts of R. officinalis are flavonoids, phenolic acids, diterpenes, triterpenes, terpenoids, and phenylpropanoids. Some of the compounds are new to science, to the genus, and to the species. Almost 30 compounds possess anticancer properties. Rosemary extracts contain abietane diterpenes, with carnosic acid, carnosol, and rosmanol being the most common. Their molecular structures are similar to three fused aromatic rings. Carnosic acid has a –COOH group at C20, carnosol has a lactone ring occurs across the B ring, and rosmanol has a –OH group at C7. Against colon and prostate cancer cells, the rosemary extract and diterpenes inhibited cell viability and induced apoptosis and G2/M phase cell cycle arrest. The inhibition of cell migration and adhesion has also been reported. The rosemary extract and diterpenes also inhibited colon and prostate cancer xenograft in mice. Rosemary extract is more cytotoxic than the diterpenes due to its polyphenols such as flavonoids and triterpenes. In vitro and in vivo cytotoxic activities involve different molecular targets and signalling pathways. Some prospects and areas for future research are suggested.
Keywords: Rosmarinus officinalis, Rosemary extracts, Carnosic acid, Carnosol, Rosmanol

This overview is on the chemistry and anticancer properties of extracts and diterpenes (carnosic acid, carnosol, and rosmanol) of rosemary. Emphasis is on colon and prostate cancer cells. There is convincing scientific evidence that carnosic acid and carnosol are promising anticancer agents. Prospects for further research are promising.
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Submitted: 26 Jul 2021
Revision: 06 Sep 2021
Accepted: 09 Sep 2021
ePublished: 29 Nov 2021
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