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J Herbmed Pharmacol. 2019;8(3): 231-237. doi: 10.15171/jhp.2019.34

Original Article

Silymarin mitigates diclofenac-induced liver toxicity through inhibition of inflammation and oxidative stress in male rats

Pantea Ramezannezhad 1 ORCID, Ali Nouri 2 * ORCID, Esfandiar Heidarian 2 ORCID

Cited by CrossRef: 12

1- Hassanpour Z, Shirazi F, Shokrpoor S, Yarahmadi R, Moghadasi N, Vosoogh M, Ashtarinezhad A. The effect of subacute co-exposure to carbon tetrachloride and diclofenac on the liver of male wistar rats. Toxicol Ind Health. 2023;39(7):364 [Crossref]
2- Dockalova H, Zeman L, Horky P. Influence of Milk Thistle (Silybum marianum) Seed Cakes on Biochemical Values of Equine Plasma Subjected to Physical Exertion. Animals. 2021;11(1):210 [Crossref]
3- Basheeruddin M, Lavanya V, Ahmed N, Jamal S. Organic osmolyte betaine mitigates the deleterious effects of Diclofenac in vivo in wistar albino rats. Braz J Pharm Sci. 2023;59 [Crossref]
4- Oyinloye O, Murtala A, Oladoja F, Okunye O, Kasumu E, Iloka P. Ethyl acetate fraction of Mucuna pruriens leaves mitigates diclofenac-induced hepatotoxicity via modulation of biochemical and histological parameters changes in Wistar Rats. PHAR. 2023;70(4):1201 [Crossref]
5- Esmaeilzadeh M, Heidarian E, Shaghaghi M, Roshanmehr H, Najafi M, Moradi A, Nouri A. Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1β gene expression in male rats. Pharmaceutical Biology. 2020;58(1):590 [Crossref]
6- Hatefi-Hesari F, Heydari M, Hosseinzadeh M, Moridi A, Bahrami R, Khaledi M, Nouri A. Protective Effect of Ellagic Acid on Induced Liver Injury. Rev Bras Farmacogn. 2021;31(6):814 [Crossref]
7- Amini S, Bagherniya M, Butler A, Askari G, Sahebkar A. The effect of medicinal plants on cirrhosis: A systematic review of clinical trials. Phytotherapy Research. 2023;37(7):3083 [Crossref]
8- Santhakumar P, Roy A, Ganesh M, Selvaraj J, Prathap L, Babu K. Ethanolic extract of Capparis decidua fruit ameliorates methotrexate-induced hepatotoxicity by suppressing oxidative stress and inflammation by modulating nuclear factor-kappa B signaling pathway. Phcog Mag. 2021;17(6):143 [Crossref]
9- Moradi A, Abolfathi M, Javadian M, Heidarian E, Roshanmehr H, Khaledi M, Nouri A. Gallic Acid Exerts Nephroprotective, Anti-Oxidative Stress, and Anti-Inflammatory Effects Against Diclofenac-Induced Renal Injury in Malerats. Archives of Medical Research. 2021;52(4):380 [Crossref]
10- Bouyahya A, Guaouguaou F, El Omari N, El Menyiy N, Balahbib A, El-Shazly M, Bakri Y. Anti-inflammatory and analgesic properties of Moroccan medicinal plants: Phytochemistry, in vitro and in vivo investigations, mechanism insights, clinical evidences and perspectives. Journal of Pharmaceutical Analysis. 2022;12(1):35 [Crossref]
11- Ekinci B, Altuner D, Suleyman B, Mammadov R, Bulut S, Suleyman Z, A. Gul M, Ergul C, Suleyman H. Effect of Thymoquinone on Diclofenac-Induced Liver Injury. International J of Pharmacology. 2022;18(6):1331 [Crossref]
12- Karimi-Matloub S, Namavari R, Hatefi-Hesari F, Sadeghi A, Karimi-Matloub R, Khaledi M, Bakhtiari A, Nouri A. The nephroprotective effect of ellagic acid against diclofenac-induced renal injury in male rats: role of Nrf2/HO-1 and NF-κB/TNF-α pathways. Biologia. 2022;77(12):3633 [Crossref]

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