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J Herbmed Pharmacol. 2019;8(2): 146-152. doi: 10.15171/jhp.2019.23

Original Article

Nephroprotective effect of silymarin against diclofenacinduced renal damage and oxidative stress in male rats

Ali Nouri 1 * ORCID, Esfandiar Heidarian 1

Cited by CrossRef: 4


1- Dockalova H, Zeman L, Baholet D, Batik A, Skalickova S, Horky P. Dose Effect of Milk Thistle (Silybum marianum) Seed Cakes on the Digestibility of Nutrients, Flavonolignans and the Individual Components of the Silymarin Complex in Horses. Animals. 2021;11(6):1687 [Crossref]
2- Abdel-Magied N, Elkady A. Possible curative role of curcumin and silymarin against nephrotoxicity induced by gamma-rays in rats. Experimental and Molecular Pathology. 2019;111:104299 [Crossref]
3- Nouri A, Heibati F, Heidarian E. Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats. Naunyn-Schmiedeberg's Arch Pharmacol. 2021;394(1):1 [Crossref]
4- Al-Yousef H, Alqahtani A, Ghani A, El-Toumy S, El-Dougdoug W, Hassan W, Hassan H. Nephroprotective and antioxidant activities of ethyl acetate fraction of Euphorbia geniculata Ortega family Euphorbiaceae. Arabian Journal of Chemistry. 2020;13(11):7843 [Crossref]
5- Ramezannezhad P, Nouri A, Heidarian E. Silymarin mitigates diclofenac-induced liver toxicity through inhibition of inflammation and oxidative stress in male rats. J Herbmed Pharmacol. 2019;8(3):231 [Crossref]
6- Nouri A, Izak-Shirian F, Fanaei V, Dastan M, Abolfathi M, Moradi A, Khaledi M, Mirshekari-Jahangiri H. Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response. Heliyon. 2021;7(11):e08358 [Crossref]
7- Al-Yousef H, Alqahtani A, Ghani A, El-Toumy S, El-Dougdoug W, Hassan W, Hassan H. Nephroprotective, cytotoxic and antioxidant activities of Euphorbia paralias. Saudi Journal of Biological Sciences. 2021;28(1):785 [Crossref]
8- Elshopakey G, Elazab S. Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats. Veterinary Sciences. 2021;8(1):9 [Crossref]
9- Afsar T, Razak S, Almajwal A, Al-Disi D. Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin-rich ethyl acetate fraction. Saudi Journal of Biological Sciences. 2020;27(9):2251 [Crossref]
10- Hassan R, Hozayen W, Abo Sree H, Al-Muzafar H, Amin K, Ahmed O, Teodoro A. Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities. Oxidative Medicine and Cellular Longevity. 2021;2021:1 [Crossref]
11- Izak-Shirian F, Najafi-Asl M, Azami B, Heidarian E, Najafi M, Khaledi M, Nouri A. Quercetin exerts an ameliorative effect in the rat model of diclofenac-induced renal injury through mitigation of inflammatory response and modulation of oxidative stress. Eur J Inflamm. 2022;20:1721727X2210865 [Crossref]
12- Moradi A, Abolfathi M, Javadian M, Heidarian E, Roshanmehr H, Khaledi M, Nouri A. Gallic Acid Exerts Nephroprotective, Anti-Oxidative Stress, and Anti-Inflammatory Effects Against Diclofenac-Induced Renal Injury in Malerats. Archives of Medical Research. 2021;52(4):380 [Crossref]