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J Herbmed Pharmacol. 2019;8(2): 146-152. doi: 10.15171/jhp.2019.23

Original Article

Nephroprotective effect of silymarin against diclofenac-induced renal damage and oxidative stress in male rats

Ali Nouri 1 * ORCID, Esfandiar Heidarian 1

Cited by CrossRef: 17

1- Dada S, Fabiyi-Edebor T, Akintoye O, Ezekpo O, Dada O, Bamikefa T, Sanya J. α-Tocopherol Ameliorates Redox Equilibrium Disorders and Reduces Inflammatory Response Caused by Diclofenac-Induced Nephrotoxicity in Male Wistar Rats. 2023; [Crossref]
2- Abdel-Magied N, Elkady A. Possible curative role of curcumin and silymarin against nephrotoxicity induced by gamma-rays in rats. Experimental and Molecular Pathology. 2019;111:104299 [Crossref]
3- Terzi F, Ciftci M. Protective effect of silymarin on tacrolimus-induced kidney and liver toxicity. BMC Complement Med Ther. 2022;22(1) [Crossref]
4- Chandra Shill M, All Rakib A, Islam Khan S, Hossain M, Alam S, Hossain H, Kumar Karmakar U, Bhuia M, Shahriar M, Mahmud Reza H, Sarkar C, Sönmez Gürer E, Sharifi-Rad J, Butnariu M, Torequl Islam M, Chan K. Polyphenol-Standardized Aphanamixis polystachya Leaf Extract Ameliorates Diabetes, Oxidative Stress, Inflammation, and Fibrosis in Streptozotocin-Induced Diabetic Rats. Journal of Food Biochemistry. 2024;2024:1 [Crossref]
5- Nouri A, Heibati F, Heidarian E. Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats. Naunyn-Schmiedeberg's Arch Pharmacol. 2021;394(1):1 [Crossref]
6- Al-Yousef H, Alqahtani A, Ghani A, El-Toumy S, El-Dougdoug W, Hassan W, Hassan H. Nephroprotective and antioxidant activities of ethyl acetate fraction of Euphorbia geniculata Ortega family Euphorbiaceae. Arabian Journal of Chemistry. 2020;13(11):7843 [Crossref]
7- Jonnalagadda R, Rathinam S, Nagappan K, Chandrasekar V. Green HPLC Method for Simultaneous Analysis of Three Natural Antioxidants by Analytical Quality by Design. 2024;107(1):14 [Crossref]
8- Al-Yousef H, Alqahtani A, Ghani A, El-Toumy S, El-Dougdoug W, Hassan W, Hassan H. Nephroprotective, cytotoxic and antioxidant activities of Euphorbia paralias. Saudi Journal of Biological Sciences. 2021;28(1):785 [Crossref]
9- Tureyen A, Demirel H, Demirkapi E, Eryavuz A, Ince S. Tubuloside A, a phenylethanoid glycoside, alleviates diclofenac induced hepato‐nephro oxidative injury via Nrf2/HO‐1. J Cellular Molecular Medi. 2023;27(21):3404 [Crossref]
10- Mansoure A, Elshal M, Helal M. Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes. International Immunopharmacology. 2024;131:111776 [Crossref]
11- Moradi A, Abolfathi M, Javadian M, Heidarian E, Roshanmehr H, Khaledi M, Nouri A. Gallic Acid Exerts Nephroprotective, Anti-Oxidative Stress, and Anti-Inflammatory Effects Against Diclofenac-Induced Renal Injury in Malerats. Archives of Medical Research. 2021;52(4):380 [Crossref]
12- Dockalova H, Zeman L, Baholet D, Batik A, Skalickova S, Horky P. Dose Effect of Milk Thistle (Silybum marianum) Seed Cakes on the Digestibility of Nutrients, Flavonolignans and the Individual Components of the Silymarin Complex in Horses. Animals. 2021;11(6):1687 [Crossref]
13- Oluwafunmilayo Ajayi J, Bukoye Oyewo E, Sanmi Adekunle A, Temidayo Ige P, Ayomide Akomolafe P. Subchronic doses of artemether-lumefantrine, ciprofloxacin and diclofenac precipitated inflammatory and immunological dysfunctions in female Wistar rats. Cytokine. 2024;176:156515 [Crossref]
14- Beigi T, Safi A, Satvati M, Kalantari-Hesari A, Ahmadi R, Meshkibaf M. Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-κB, and TNF-α in male Wistar rats. Life Sciences. 2022;304:120679 [Crossref]
15- Ghareeb O, Ramadhan S. Prophylactic Efficacy of Silymarin upon Renal Dysfunction Induced by Copper Oxide Nanoparticle. JHTD. 2023;(36):29 [Crossref]
16- Ramezannezhad P, Nouri A, Heidarian E. Silymarin mitigates diclofenac-induced liver toxicity through inhibition of inflammation and oxidative stress in male rats. J Herbmed Pharmacol. 2019;8(3):231 [Crossref]
17- Nouri A, Izak-Shirian F, Fanaei V, Dastan M, Abolfathi M, Moradi A, Khaledi M, Mirshekari-Jahangiri H. Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response. Heliyon. 2021;7(11):e08358 [Crossref]
18- Elshopakey G, Elazab S. Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats. Veterinary Sciences. 2021;8(1):9 [Crossref]
19- Afsar T, Razak S, Almajwal A, Al-Disi D. Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin-rich ethyl acetate fraction. Saudi Journal of Biological Sciences. 2020;27(9):2251 [Crossref]
20- Hassan R, Hozayen W, Abo Sree H, Al-Muzafar H, Amin K, Ahmed O, Teodoro A. Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities. Oxidative Medicine and Cellular Longevity. 2021;2021:1 [Crossref]
21- Izak-Shirian F, Najafi-Asl M, Azami B, Heidarian E, Najafi M, Khaledi M, Nouri A. Quercetin exerts an ameliorative effect in the rat model of diclofenac-induced renal injury through mitigation of inflammatory response and modulation of oxidative stress. Eur J Inflamm. 2022;20:1721727X2210865 [Crossref]
22- Shokri F, Yari A. Nanocomposite of Palladium Nanoparticles Anchored on Boron Nitride Nanosheets as a Sensor for Liver Treatment Drug Silymarin. ACS Appl Electron Mater. 2023;5(12):7087 [Crossref]

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