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J Herbmed Pharmacol. 2019;8(2): 69-77. doi: 10.15171/jhp.2019.12

Review

Heavy metals detoxification: A review of herbal compounds for chelation therapy in heavy metals toxicity

Reza Mehrandish 1 ORCID, Aliasghar Rahimian 2, Alireza Shahriary 1 * ORCID

Cited by CrossRef: 64

1- Liu J, Hung Y, Lin S, Shvetsov S, Rudyak V, Emelyanenko A, Liu C. Recyclable liquid crystal polymeric sensor beads based on the assistance of radially aligned liquid crystals. Polym J. 2021;53(2):373 [Crossref]
2- Heo S, Moon N, Kim J. Dietary interventions to reduce heavy metal exposure in antepartum and postpartum women: a systematic review. Womens Health Nurs. 2024;30(4):265 [Crossref]
3- Ahmed M, Khan K, Ahmad S, Aati H, Ovatlarnporn C, Rehman M, Javed T, Khursheed A, Ghalloo B, Dilshad R, Anwar M. Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development. Molecules. 2022;27(13):4113 [Crossref]
4- Anujna R, Mohanalakshmi M, Rajashree V, Renuka R, Meenakshi P. Exploring the leafy coriander Coriandrum sativum L. (Apiaceae): A comprehensive review on the metabolomics properties. South African Journal of Botany. 2025;181:258 [Crossref]
5- Balachandran C, Hirose M, Tanaka T, Zhu J, Yokoi K, Hisamatsu Y, Yamada Y, Aoki S. Design and Synthesis of Poly(2,2′-Bipyridyl) Ligands for Induction of Cell Death in Cancer Cells: Control of Anticancer Activity by Complexation/Decomplexation with Biorelevant Metal Cations. Inorg Chem. 2023;62(36):14615 [Crossref]
6- Dobrzański Z, Chojnacka K, Trziszka T, Opaliński S, Bobak Ł, Konkol D, Korczyński M. The Effect of Dietary Humic Preparations on the Content of Essential and Non-Essential Chemical Elements in Hen Eggs. Animals. 2020;10(8):1252 [Crossref]
7- Gu J, Dong Y. Preparing Multi-Functional Protein Textiles by the Flavonoid-Rich Ginkgo Biloba L. Leaf Extracts . Journal of Natural Fibers. 2024;21(1) [Crossref]
8- Alam T, Shahid F, Abidi S, Parwez I, Khan F. Thymoquinone supplementation mitigates arsenic-induced cytotoxic and genotoxic alterations in rat liver. Journal of Trace Elements in Medicine and Biology. 2022;74:127067 [Crossref]
9- Ebrahimi R, Ebrahimi M, Shakeri M. Mitigating the Adverse Effects of Lead and Cadmium Heavy Metals-Induced Oxidative Stress by Phytogenic Compounds in Poultry. Poultry. 2023;2(2):235 [Crossref]
10- Bjørklund G, Oliinyk P, Lysiuk R, Rahaman M, Antonyak H, Lozynska I, Lenchyk L, Peana M. Arsenic intoxication: general aspects and chelating agents. Arch Toxicol. 2020;94(6):1879 [Crossref]
11- Patel V, Panara K, Acharya R. Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study. Journal of Ayurveda and Integrative Medicine. 2021;12(4):689 [Crossref]
12- Rohani M. Pesticides toxicity in fish: Histopathological and hemato-biochemical aspects – A review. Emerging Contaminants. 2023;9(3):100234 [Crossref]
13- Gheybi F, Rajabian F, Tayarani-Najaran Z, Adibi A, Alavizadeh S, Kesharwani P, Sahebkar A. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. Journal of Trace Elements in Medicine and Biology. 2023;80:127291 [Crossref]
14- Bano H, Rather R, Malik S, Bhat M, Khan A, Américo-Pinheiro J, Mir I. Effect of Seasonal Variation on Pollution Load of Water of Hokersar Wetland: a Case Study of Queen Wetland of Kashmir, J&K, India. Water Air Soil Pollut. 2022;233(12) [Crossref]
15- Yang C, Chien M, Chao P, Huang C, Chen C. Investigation of toxic heavy metals content and estimation of potential health risks in Chinese herbal medicine. Journal of Hazardous Materials. 2021;412:125142 [Crossref]
16- Silva R, Marques de Oliveira Moraes V, Marinho Dos Santos V, Oliveira Granero F, Malaguti Figueiredo C, Pereira Silva L. Heavy metal accumulation efficiency and subsequent of cytogenotoxicity evaluation in the medicinal plant Equisetum hyemale. Journal of Toxicology and Environmental Health, Part A. 2022;85(24):989 [Crossref]
17- Nezhad M, Foroozandeh A, Amoli H, Hasanzadeh M. Chelating agent-assisted extraction of toxic elements towards ensuring food and beverage safety: Advances and challenges. TrAC Trends in Analytical Chemistry. 2025;183:118104 [Crossref]
18- Nobahar A, Carlier J, Miguel M, Costa M. A review of plant metabolites with metal interaction capacity: a green approach for industrial applications. Biometals. 2021;34(4):761 [Crossref]
19- Sharma N, Gaur N, Vishwakarma S, Gupta J, Dalua S, Tiwari P, Valavan R. Heavy Metals in Homoeopathic Mother Tinctures – Is it a Cause for Concern? . ahr. 2023;8(1):19 [Crossref]
20- Singh A, Kostova I. Health effects of heavy metal contaminants Vis-à-Vis microbial response in their bioremediation. Inorganica Chimica Acta. 2024;568:122068 [Crossref]
21- Safari Maleki A, Hayes A, Karimi G. Enhancing renal protection against cadmium toxicity: the role of herbal active ingredients. 2024;13(6) [Crossref]
22- Bjørklund G, Cruz-Martins N, Goh B, Mykhailenko O, Lysiuk R, Shanaida M, Lenchyk L, Upyr T, Rusu M, Pryshlyak A, Shanaida V, Chirumbolo S. Medicinal Plant-derived Phytochemicals in Detoxification. CPD. 2024;30(13):988 [Crossref]
23- Yang H, Zheng Q, Zhang P, Nie G, Ali T, Raza S. Fabrication of MXene (Ti2C3Tx) based conducting polymer materials and their applications as anticancer and metal ions removal from wastewater. Surfaces and Interfaces. 2023;36:102493 [Crossref]
24- Ali T, Abdul Keyon A, Mahat N, Mohamed Huri M. An updated ecotoxicological evaluation and health risk assessment of metal contaminants in Perna viridis mussel harvested on March to August 2018 from Pasir Gudang Coastal Area, Malaysia. Journal of Food Composition and Analysis. 2024;132:106288 [Crossref]
25- Ali A, Kouvari M, Riaz S, Naumovski N, Liao L, Khan A, Khalid W, Zeng X, Manzoor M. Potential of Allium sativum in blood pressure control involves signaling pathways: A narrative review. Food Frontiers. 2023;4(4):1666 [Crossref]
26- Akter R, Neelotpol S, Kabir M. Effect of Allium sativum methanol extract in amelioration of arsenic-induced toxicity in Swiss albino mice. Phytomedicine Plus. 2022;2(1):100192 [Crossref]
27- Monga A, Fulke A, Dasgupta D. Recent developments in essentiality of trivalent chromium and toxicity of hexavalent chromium: Implications on human health and remediation strategies. Journal of Hazardous Materials Advances. 2022;7:100113 [Crossref]
28- Dey P, Kaur M, Khajuria A, Kaur D, Singh M, Alajangi H, Singla N, Singh G, Barnwal R. Heavy metal ion detection with Nano-Engineered Materials: Scaling down for precision. Microchemical Journal. 2024;196:109672 [Crossref]
29- Abdollahzade N, Majidinia M, Babri S. Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity. Mol Biol Rep. 2021;48(9):6603 [Crossref]
30- Monga Y, Sharma S, Singh S, Gupta A. Biochar, Clay, Zeolites, and Microorganism-based Methods for Remediation of Heavy Metals. CGC. 2024;11(1):2 [Crossref]
31- Fannami I, Garba S, Chiroma S. Adansonia digitata L. fruit shell extract alleviates lead-induced neurotoxicity in mice via modulation of oxidative stress and a possible chelating activity. Journal of Trace Elements in Medicine and Biology. 2022;74:127074 [Crossref]
32- Alam T, Rizwan S, Farooqui Z, Abidi S, Parwez I, Khan F. Oral Nigella sativa oil administration alleviates arsenic-induced redox imbalance, DNA damage, and metabolic and histological alterations in rat liver. Environ Sci Pollut Res. 2021;28(30):41464 [Crossref]
33- Bjørklund G, Shanaida M, Lysiuk R, Butnariu M, Peana M, Sarac I, Strus O, Smetanina K, Chirumbolo S. Natural Compounds and Products from an Anti-Aging Perspective. Molecules. 2022;27(20):7084 [Crossref]
34- Rob M, Akhter D, Islam T, Bhattacharjya D, Shoaib Khan M, Islam F, Chen J. Copper stress in rice: Perception, signaling, bioremediation and future prospects. Journal of Plant Physiology. 2024;302:154314 [Crossref]
35- Raeeszadeh M, Khalili T, Sharifi H, Mohammadzadeh P. Ameliorative effect of Brassica oleracea var. Italica extract on oxidative damage of arsenic in the rat’s brain: biochemical, pathological, and behavioral aspects. Metab Brain Dis. 2023;38(4):1323 [Crossref]
36- Fu Z, Yao Y, Haq M, Liu Y, Yang D, Yang H, Wu Y. Glutathione's role in mitigating cadmium stress in Pogostemon cablin: Insights from combined transcriptomic and metabolomic approaches. Journal of Hazardous Materials. 2025;491:137921 [Crossref]
37- Adelnia H, Ensandoost R, Shebbrin Moonshi S, Gavgani J, Vasafi E, Ta H. Freeze/thawed polyvinyl alcohol hydrogels: Present, past and future. European Polymer Journal. 2022;164:110974 [Crossref]
38- Peivasteh-roudsari L, Barzegar-bafrouei R, Sharifi K, Azimisalim S, Karami M, Abedinzadeh S, Asadinezhad S, Tajdar-oranj B, Mahdavi V, Alizadeh A, Sadighara P, Ferrante M, Conti G, Aliyeva A, Mousavi Khaneghah A. Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review. Heliyon. 2023;9(7):e18140 [Crossref]
39- Hamai-Amara H, Abou-Saleh H, A. Al-Ghouti M, Crovella S, Saadaoui I, Soubra L. Microalgae potential to protect from heavy metals-induced carcinogenicity. Algal Research. 2024;78:103411 [Crossref]
40- Maghchiche A, Meghchiche N. Current Awareness and Knowledge of Heavy Metals. AJESRE. 2024;16(1):17 [Crossref]
41- Esmaeili Bidhendi M, Parandi E, Mahmoudi Meymand M, Sereshti H, Rashidi Nodeh H, Joo S, Vasseghian Y, Mahmoudi Khatir N, Rezania S. Removal of lead ions from wastewater using magnesium sulfide nanoparticles caged alginate microbeads. Environmental Research. 2023;216:114416 [Crossref]
42- Bjørklund G, Rahaman M, Shanaida M, Lysiuk R, Oliynyk P, Lenchyk L, Chirumbolo S, Chasapis C, Peana M. Natural Dietary Compounds in the Treatment of Arsenic Toxicity. Molecules. 2022;27(15):4871 [Crossref]
43- Ghafarifarsani H, Fazle Rohani M, Raeeszadeh M, Ahani S, Yousefi M, Talebi M, Sazzad Hossain M. Pesticides and Heavy Metal Toxicity in Fish and Possible Remediation – A Review. 2024;24(4):1007 [Crossref]
44- Kerdsomboon K, Chumsawat W, Auesukaree C. Effects of Moringa oleifera leaf extracts and its bioactive compound gallic acid on reducing toxicities of heavy metals and metalloid in Saccharomyces cerevisiae. Chemosphere. 2021;270:128659 [Crossref]
45- Wu X, Patthamawan K, Okuhata Y. Sensitive detection of heavy metal stress in aquatic plants by dissolved oxygen-quenched fluorescence/materials movement-induced beam deflection method. ANAL SCI. 2023;39(12):1993 [Crossref]
46- Nawabjan S, Zhang F, G S M, Yu X, Yan W, Balu K, Chow B. Preparation, characterization of pearl powder and its in vivo detoxification potential for heavy metals in mice. Journal of Hazardous Materials Advances. 2025;17:100524 [Crossref]
47- Berillo D, Ermukhambetova A. The review of oral adsorbents and their properties. Adsorption. 2024;30(6):1505 [Crossref]
48- Vázquez Cervantes G, González Esquivel D, Ramírez Ortega D, Blanco Ayala T, Ramos Chávez L, López-López H, Salazar A, Flores I, Pineda B, Gómez-Manzo S, Pérez de la Cruz V. Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure. Cells. 2023;12(21):2537 [Crossref]
49- Okta F, Aulena D, Yuliana P, Tambunan R. In Vitro Angiotensin-Converting Enzyme (ACE) Inhibition Test on Extract Dayak Onion Herb (Eleutherine americana (Aubl.) Merr. ex K. Heyne). sciphar. 2023;2(2):24 [Crossref]
50- Chen F, Zhu J, Yu L, Zhang Q, Guo M, Tian F, Zhai Q. Effect of Lactiplantibacillus plantarum CCFM8661 on serum metabolites and gut microbiota in a lead-exposed population. International Journal of Biological Macromolecules. 2024;261:129815 [Crossref]
51- Algandaby M. Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1. Futur J Pharm Sci. 2025;11(1) [Crossref]
52- Rojas P, Ruiz-Sánchez E, Ríos C, Ruiz-Chow Á, Reséndiz-Albor A. A Health Risk Assessment of Lead and Other Metals in Pharmaceutical Herbal Products and Dietary Supplements Containing Ginkgo biloba in the Mexico City Metropolitan Area. IJERPH. 2021;18(16):8285 [Crossref]
53- El-Said K, Hussein S, Alrashdi B, Mahmoud H, Ibrahim M, Elbakry M, El-Tantawy H, Kabil D, El-Naggar S. Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice. Molecules. 2022;27(2):559 [Crossref]
54- Giri S, Mahato M, Parveen N, Singh A. Human health risk assessment of metal contamination in cereals and pulses in the mica mining areas of Jharkhand, India. Journal of Hazardous Materials Advances. 2024;16:100511 [Crossref]
55- Guo J, Knol L, Yang X, Kong L. Dietary fiber intake is inversely related to serum heavy metal concentrations among US adults consuming recommended amounts of seafood: NHANES 2013–2014. Food Frontiers. 2022;3(1):142 [Crossref]
56- Delgado-Ruiz R, Romanos G. “Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”. Medical Hypotheses. 2023;179:111160 [Crossref]
57- Tahir R, Tahir S, Afzal F, Liang J, Yang S. Novel protective aspects of dietary polyphenols against pesticidal toxicity and its prospective application in rice-fish mode: A Review. Fish & Shellfish Immunology. 2024;146:109418 [Crossref]
58- Nizamlıoğlu M, Öncel H, Nizamlıoğlu F. Ağır Metal Maruziyetinin Detoksifikasyonunda Tıbbi Aromatik Bitkilerin Terapötik Etkileri. 2024;17(Özel Sayı (1)):57 [Crossref]
59- Mishra D, Awasthi H, Srivastava D, Fatima Z. Phytochemical: a treatment option for heavy metal induced neurotoxicity. 2022;19(3):513 [Crossref]
60- Prottay A, Bappi M, Akbor M, Asha A, Bhuia M, Shafin A, Mia M, Mubarak M, Lima M, Coutinho H, Islam M. Sclareol exerts an anti-inflammatory effect, possibly through COXs inhibition pathway: In vivo and in silico studies. Pharmaceutical Science Advances. 2024;2:100029 [Crossref]
61- Budi H, Catalan Opulencia M, Afra A, Abdelbasset W, Abdullaev D, Majdi A, Taherian M, Ekrami H, Mohammadi M. Source, toxicity and carcinogenic health risk assessment of heavy metals. 2024;39(1):77 [Crossref]
62- Ogudov A, Savchenko O, Chuenko N, Bolshakov V, Novikova I. On the issue of substantiating a high degree of one-time marginal probability of detecting pentasodium salt of diethylenetriaminepentaacetic acid in the working area. Med tr prom èkol. 2022;62(10):689 [Crossref]
63- Ibrahim A, Alamir S, Al-Omairi M, Salman B, Batakoushy H, Hegazy M, Al-Harrasi A. Tracking the Variations in Trace and Heavy Elements in Smoking Products Marketed in Oman and Egypt: Risk Assessment After Implementation of Constraining Protocols. Biol Trace Elem Res. 2025;203(1):556 [Crossref]
64- Omidvar-Motlagh M, Es’haghi Z. Magnetic Porous Ion Imprinted Polymer Based on Surface Polymerization and Nano-ZnO as Sacrificial Support for Selective Extraction and determination of Pb (II) in Water Samples and Cosmetics. Water Air Soil Pollut. 2024;235(3) [Crossref]
65- Sharma S, Sharma V. Alleviation of Lead Nitrate-Induced Nephrotoxicity by Garlic Essential Oil in Albino Mice: A Comprehensive Study on Inflammation and Genotoxicity. TI. 2024;:283 [Crossref]
66- Aslanzadeh M, Saboora A, Moradlou O. Phytoremediation potential of duckweed (Lemna minor L.) for hexavalent chromium removal in synthetic wastewater: unveiling physiological response and defense mechanisms against excessive heavy metal uptake. Int J Environ Sci Technol. 2024;21(16):10155 [Crossref]
67- Bruno F, Nava V, Zappalà S, Costa G, Fazio F, Parrino V, Licata P. Mineral composition in mussel Mytilus galloprovincialis and clam Tapes decussatus from Faro Lake of Messina: risk assessment for human health. Front Toxicol. 2024;6 [Crossref]
68- Caglayan C, Kandemir F, Ayna A, Gür C, Küçükler S, Darendelioğlu E. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metab Brain Dis. 2022;37(6):1931 [Crossref]
69- Moldoveanu C, Tomoaia-Cotisel M, Sevastre-Berghian A, Tomoaia G, Mocanu A, Pal-Racz C, Toma V, Roman I, Ujica M, Pop L. A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases. Molecules. 2024;30(1):43 [Crossref]
70- Omidifar N, Nili-Ahmadabadi A, Nakhostin-Ansari A, Lankarani K, Moghadami M, Mousavi S, Hashemi S, Gholami A, Shokripour M, Ebrahimi Z. RETRACTED ARTICLE: The modulatory potential of herbal antioxidants against oxidative stress and heavy metal pollution: plants against environmental oxidative stress. Environ Sci Pollut Res. 2021;28(44):61908 [Crossref]

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