Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 8 1 2019 01 01 Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts 51 55 10.15171/jhp.2019.09 EN Dheeraj S. Randive https://orcid.org/0000-0003-2000-1492 Mangesh A. Bhutkar Somnath D. Bhinge https://orcid.org/0000-0002-5959-5833 Kiran P. Shejawal Poonam R. Sanap Pranoti D. Patil Suhas A. Mane Journal Article 10.15171/jhp.2019.09 2018 05 16 2018 12 10 Introduction: The aim of the current analysis was to judge the hypoglycemic action of the phyto-extracts of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana using suitable in vitro approaches.Methods: The hypoglycemic activity of the phyto-material extracts was evaluated by employing various in-vitro methods namely glucose diffusion, amylolysis kinetics and glucose adsorption capacity.Results: The extracts of L. siceraria, C. dactylon and S. rebaudiana exhibited glucose dialysis retardation indices (GDRI) of 48.14%, 37.03% and 29.62%, respectively at 60 minutes which were reduced to 15.78%, 10.52% and 18.42%, respectively at 120 minutes. All the plant extracts used in the study adsorbed glucose and their adsorptions markedly enhanced with increase in sugar concentration.Conclusion: From the outcome of the assay it can be concluded that the extracts of L. siceraria, C. dactylon and S. rebaudiana have hypoglycemic activity as observed in various in-vitro assays. However, the beneficial actions require to be verified by adopting various in vivo techniques along with clinical trials for their efficient use as potential remedial moiety.