Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 10 4 2021 10 01 Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats 394 400 10.34172/jhp.2021.46 EN Godwin Christian Akuodor https://orcid.org/0000-0002-4219-0258 Pius Monday Udia https://orcid.org/0000-0001-5374-3092 Sylvester Chika Ohadoma https://orcid.org/0000-0002-2624-9846 Ifeanyi M. Obi https://orcid.org/0000-0003-1100-9396 Anthony Uchenna Megwas https://orcid.org/0000-0002-5978-1046 Jane Ugochi Chilaka https://orcid.org/0000-0001-8038-9092 Kingsley Chimsorom Chilaka https://orcid.org/0000-0001-7709-3805 Francis Vincent Udoh https://orcid.org/0000-0002-2692-5170 Journal Article 10.34172/jhp.2021.46 2020 06 10 2020 09 02 Introduction: Salacia lehmbachii is used traditionally for the treatment of diabetes mellitus. This study investigated the hypoglycaemic potentials of ethanol leaf extract of S. lehmbachii and its effects on alloxan-induced diabetic rats’ haematological parameters. Methods: A total of 36 male Wistar rats including normal, diabetic untreated, and diabetic treated ones were used in this study. Diabetes was induced by a single intraperitoneal injection of 150 mg/kg of alloxan. When confirmed diabetes, the rats were orally administered 100 mg/kg, 200 mg/kg, and 400 mg/kg daily of the leaf extract for 21 days. The blood glucose levels and haematological parameters were determined in diabetic treated rats compared with the controls. Results: The ethanol leaf extract of S. lehmbachii significantly reduced the blood glucose levels of alloxan-induced diabetic rats when compared with the diabetic control (P < 0.01). The extract also significantly (P < 0.01) improved the haematological parameters of treated rats at three doses employed. Conclusion: It can be concluded that the ethanol leaf extract of S. lehmbachii possesses antihyperglycaemic properties and could be considered a potential candidate for the development of new drugs in the treatment of anaemic conditions.