Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 12 3 2023 06 01 Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats 448 452 10.34172/jhp.2023.50 EN Siska Siska https://orcid.org/0000-0003-4830-9261 Endang Hanani https://orcid.org/0000-0002-2865-4458 Tahyatul Bariroh https://orcid.org/0000-0003-2327-1690 Benny Febrianto https://orcid.org/0000-0003-0123-0353 Anggraita Dewi Amalia Putri Pratiwi https://orcid.org/0000-0002-4895-4108 Nadhif Naufala Yaner https://orcid.org/0000-0002-2888-152X Nur Alfaeni Fitri https://orcid.org/0000-0003-2458-3645 Journal Article 10.34172/jhp.2023.50 2022 12 06 2023 03 04 Introduction: The green cactus Pereskia bleo is thought to have anti-cancer, anti-tumor, anti-inflammatory, and anti-rheumatic properties. Additionally, it treats hypertension and diabetes; However, no scientific evaluation of its antihypertensive activity has been conducted. The purpose of this study was to investigate the effects of oral administration of P. bleo extract (PBE) on male rats’ blood pressure, urine volume, and sodium and potassium levels. Methods: Sodium chloride (NaCl) solution (4%) was administered orally to induce hypertension. A non-invasive tail method was used to measure blood pressure. The sodium and potassium concentrations as well as the total volume of urine were measured from the collected urine. Results: Hypertensive rats’ blood pressure was reduced by 250, 500, and 1000 mg/kg of PBE. Similar to the positive control group (captopril dose of 1.25 mg/kg BW), the most significant drop in blood pressure was occurred at the dose of 1000 mg/kg BW (P>0.05). All treatment groups saw an increase in urinary sodium and potassium levels. Conclusion: In NaCl-induced hypertensive rats, oral administration of P. bleo ethanolic extract decreased blood pressure to the standard value by increasing urinary sodium and potassium levels. Hence, it might be used as an anti-hypertensive agent.