Eric Wei Chiang Chan*  , Siu Kuin Wong , Hung Tuck Chan
Implication for health policy/practice/research/medical education: The prospects of further research on the phytochemistry and pharmacological properties of V. inermis are rewarding. New compounds are still being reported. Among the pharmacological properties of V. inermis, the amelioration of motor tic disorders warrants further research, notably on the compounds and mechanisms involved. Comparisons with other Volkameria species would be interesting.
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Arsalan Khaledifar , Mohammad Reza Khosravi Farsani* , Elham Raeisi
Implication for health policy/practice/research/medical education: The protective effects of Ber in preventing or reducing complications caused by doxorubicin consumption were shown in this study. The cardioprotective effects of Ber were mainly due to the antioxidant and anti-inflammatory activities, and it also could improve heart function. Therefore, this herbal substance might be used under the supervision of physicians to reduce cardiotoxicity in cancer treatment centers to minimize the side effects of chemotherapy.
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Himanshu Kanaiyalal Solanki , Kalpana Ashish Dabhade* , Giridharan Bupesh , Vijaya Anand Arumugam , Periyasamy Visvanathan , Macha Bhaskar , Konda Mani Saravanan
Implication for health policy/practice/research/medical education: The phytoconstituents of aqueous leaf and rhizome extracts of Kaempferia pulchra were discovered to have many therapeutic properties, particularly for diabetes management.
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Rehab Fawzy Abdel-Rahman* , Hany M Fayed , Marwan A Mohamed , Alyaa F Hessin , Gihan F Asaad , Sahar S AbdelRahman , Abeer A Salama , Mahmoud S Arbid , Hanan A Ogaly
Implication for health policy/practice/research/medical education: Our research showed that apigenin has the potential to be a therapeutic medication for hepatic fibrosis. However, further studies are needed to establish the clinical applicability of APG treatment in active liver fibrogenesis human cases.
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Supavadee Boontha* , Prakaifa Jaibia , Supanuch Punyuang , Krit Jaiwan , Thamonwan Luangtrakul , Kamchai Saepang , Benjaporn Buranrat , Tasana Pitaksuteepong
Implication for health policy/practice/research/medical education: Cassia fistula pod shell and leaf extracts exhibited anticancer activities on human breast cancer MCF-7 cells. These extracts might be potential sources of chemotherapeutic agents for breast cancer treatment.
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Matin Kordestani , Marzieh Rashidipour , Hossein Mahmoudvand , Shoukofeh Jalali , Fahimeh Kooshki*
Implication for health policy/practice/research/medical education: We revealed that thymol-loaded chitosan nanocomposite (TLCN) had promising antibacterial effects against cariogenic bacterial causes. Nevertheless, supplementary examinations are obligatory to elucidate the precise mechanisms and its toxicity.
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Nader Sadeghi , Hoda Sadeghi , Dharshini Nangaru Mohan , Asghar Sepahvand , Arash Alizadeh , Shirin Garavand*
Implication for health policy/practice/research/medical education: Our findings revealed the promising antifungal effects of F. macrecolea essential oil and terpinolene (main composition) against C. albicans sensitive and resistant to nystatin with no significant cytotoxic effect on normal cell lines. Hence, they might be used against candidiasis.
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Eman Hassan Abdel aziz Sharaf* , Enas Ali Kamel, Marwa Mosaad Hassan
Implication for health policy/practice/research/medical education: Almond and primrose oils improved the lipid and neurochemical parameters in ovariectomized rats and ameliorated the histological changes in the rat hippocampal brain tissue. These essential oils might be recommended to physicians as for the treatment of cardiovascular disorders and mood and memory defects in ovariectomized women.
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Chandana Roy , Pratiti Ghosh*
Implication for health policy/practice/research/medical education: Renal drug efflux by p-glycoprotein has been a major hurdle in its bioavailability, which may be circumvented by screening for its natural reno-protective nontoxic inhibitors, viz., atisine, embelin, phylloquinone, or stigmasterol which may be synergistically administered with the treatment drugs to alleviate the disease.
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Hadeer Saad Mohamed , Tahany Kholief , Radwa Wahid Mohamed* , Amira Abd El-Rhman
Implication for health policy/practice/research/medical education: The use of black chia and garden cress seeds improves lesions of hyperglycemia and reduces the related side effects. These seeds might be recommended to physicians for the treatment of diabetes.
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Prasoborn Rinthong , Pawitra Pulbutr , Chawannuch Mudjupa*
Implication for health policy/practice/research/medical education: The phytoconstituents of Triphala, specifically beta-sitosterol, processed the substantial binding affinity with HMG-CoA reductase, a rate-limiting enzyme for the endogenous cholesterol synthesis. These results indicate that the phytoconstituents in Triphala may exert their antidyslipidemic effects via HMG-CoA reductase inhibition. Therefore, these Triphala-derived phytochemical compounds are valuable candidates for the development of alternative treatments against dyslipidemia.
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Patipat Thinwang , Natthapon Samakchan , Rerngwit Boonyom*
Implication for health policy/practice/research/medical education: Garlic and turmeric extracts exhibited anti-T3SS in Salmonella Typhimurium by interruption of SPI-1 T3SS regulatory genes expression. Hence, these herbs have promising values to develop novel anti-T3SS therapeutic agents.
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Mohaddeseh Kamranikheiri* , Muberra Kosar
Implication for health policy/practice/research/medical education: The results of the current investigation revealed the high anticancer potency of vitamin C and Citrus sinensis against human lung cancer cell lines. Although more studies are required, however, they can be considered new agents for cancer therapy.
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Arman Mahmud Khan , Md. Arman Sharif , Rahagir Salekeen , Md. Hafijur Rahman , Sakib Mahmud , Partha Biswas , Md. Nazmul Hasan , Kazi Mohammed Didarul Islam , Md. Morsaline Billah , Md. Emdadul Islam*
Implication for health policy/practice/research/medical education: The findings of this study suggest that bioactive compounds of garlic extract have potent therapeutic features as anti-inflammatory agents that can help to explore and investigate new potentially active therapeutics from garlic against lipoxygenase mediated chronic inflammatory illness.
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Vara Prasad Saka , Chitra Vellapandian , Damodharan Narayanasamy*
Implication for health policy/practice/research/medical education: The current study demonstrated that hispolon pyrazole (HP) and hispolon monomethyl ether pyrazole (HMEP) have neuroprotective potential against RF-EMR from mobile phones. These chemicals might be used to develop neuroprotective drugs.
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David Nyaga Ngai* , Cromwell Mwiti Kibiti , Mathew Piero Ngugi
Implication for health policy/practice/research/medical education: The present study revealed new knowledge about the efficacy of the two P. africana extracts in the enhancement of spatial memory. In addition, the study also established the presence of phytocompounds with valuable medicinal properties, including enzymatic and non-enzymatic antioxidant activities which are necessary for alleviating oxidative stress linked to Alzheimer’s disease (AD) pathology. Therefore, the extracts could be useful in managing AD.
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Ali Kharazmkia , Javad Ghasemian Yadegari , Mohammad Mohammadian , Rehman Ali , Hossein Mahmoudvand*
Implication for health policy/practice/research/medical education: This work revealed the potent in vitro anti-Giardia activity of limonene (LMN) against G. lamblia with the maximum activity at 50 and 100 μg/mL. We also showed that induction of apoptosis could be considered as one of the cellular mechanisms of action of limonene; nevertheless, additional surveys are necessary to consider it as a new drug.
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