Logo-jhp
J Herbmed Pharmacol. 2016;5(3): 92-98.
  Abstract View: 3398
  PDF Download: 1699

Original Article

Gastroprotective effect of plumbagin and ethanolic extract of plumbaginales in experimentally-induced ulcer

Sibi P. Ittiyavirah 1*, Ann Shine Paul 1

1 Department of Pharmacology, DPS, RIMSR, Puthupally, Kottayam, Kerala, India
*Corresponding Author: Email: sibitho@gmail.com

Abstract

Introduction: Medicinal plants with phenolic compounds have been shown to have antimicrobial and antioxidant activities. The objective of the study was to evaluate the anti-ulcer effects of ethanolic extracts of Plumbaginales namely P. auriculata, P. indica and P. zeylanica and plumbagin in aspirin and ethanol induced gastric ulcer models.Methods: In vivo studies including DPPH scavenging assay, lipid peroxidase inhibition assay, acid neutralizing capacity test, aspirin- and ethanol-induced ulcer models were performed to assess the antioxidant and antiulcer effects of plants. By using the models of Aspirin (200 mg/kg, 1 hour after the administration of last dose of the extract/ranitidine) and ethanol (1 mL/200 g, 90%) induced ulcer, animals were randomly divided into three groups of six animals each. Group I served as positive control, group II acted as standard and received ranitidine (20 mg/kg). The group III was treated with ethanolic extract by oral route in a dose of 300 mg/kg for a period of 5 days. The animals were sacrificed and the stomach was then excised and cut along the greater curvature, washed carefully with 5.0 mL of 0.9% NaCl and ulcers were scored.Results: Both the aspirin- and ethanol-induced models of ulcer with various extracts of Plumbaginales showed significant acid neutralizing and antioxidant properties.Conclusion: This study suggests that root extracts of P. auriculata may have good quality potentials for use in peptic ulcer diseases and that P. auriculata possesses an antiulcer effect.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 3399

Your browser does not support the canvas element.


PDF Download: 1699

Your browser does not support the canvas element.

EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)