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J Herbmed Pharmacol. 2014;3(1): 47-51.
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Original Article

The effects of green tea extract on teratogenicity induced by low frequency electromagnetic field on bone marrow Balb/C mice embryo

Javad Baharara 1*, Saeedeh Zafar Balanejad 1, Esmat Kamareh 2, Majid Asadi-Samani 3

1 Research Center for Animal Development Applied Biology & Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
2 Cell & Developmental Biology Department, Mashhad Branch, Islamic Azad University, Mashhad, Iran
3 Medical Plants Research Center, Shahrekord University of Medicine Sciences, Shahrekord, Iran
*Corresponding Author: *Corresponding author: Javad Baharara, Tell: +985118437092,, Email: baharara@yahoo.com

Abstract

Introduction: Electromagnetic fields produce free radicals which might be teratogen. Camellia sinensis is rich in natural antioxidants and antioxidants can neutralize free radicals effects. In present research the effect of C. sinensis extract in reduction of teratogenicity induced by electromagnetic field with 50 gauss intensity was studied on bone marrow of Balb/C mice fetuses.

Methods: In this experimental study, 24 Balb/C pregnant mice were randomly divided into four groups: control, sham exposed (off position), experimental 1 (electromagnetic field with 50-gauss intensity) and experimental 2 (treatment by C. sinensis extract + electromagnetic field with 50-gauss intensity). After treatment period, the bone marrow aspirates of Balb/C mice embryos were prepared and studied by Giemsa. The quantitative data were analyzed by Kruskal-Wallis and Kolmogorov- Smirnov using SPSS16 software at the level of p<0.05.

Results: The mean number of promyelocytes, myelocytes, erythrocytes, necrotic and apoptotic cells in experimental group1 compared with sham exposed embryos showed significant increase but the mean number of eosinophils in experimental group 1 compared with sham exposed embryos showed significant decrease. The mean number of promyelocyte and erythrocyte in experimental group 2 compared with experimental group 1 showed significant decrease. The mean of necrotic and apoptotic cells, in experimental group 2 compared with experimental group 1 showed significant increase.

Conclusion: Usage of C. sinensis can decrease the damage due to teratogenicity induced by low frequency electromagnetic field in some cells.


Implication for health policy/practice/research/medical education:

Camellia sinensis offsets the change in the number of eosinophils and promyelocytes caused by electromagnetic field and hence its consumption is recommended for radiologists and broadcasting and telecommunication personnel.

Please cite this paper as: Baharara J, Zafar-Balanejad S, Kamareh E, Asadi-Samani M. The effects of green tea extract on teratogenicity induced by low frequency electromagnetic field on bone marrow Balb/C mice embryo. J Herbmed Pharmacol 2014; 3(1): 47-51.

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ePublished: 01 Jun 2014
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