Logo-jhp
J Herbmed Pharmacol. 2015;4(2): 56-60.
  Abstract View: 4052
  PDF Download: 3020

Original Article

The effects of celery leave extract on male hormones in rats

Wesam Kooti 1, Maryam Ghasemi-boroon 2, Mehri Ghafourian 3, Majid Asadi-Samani 4*, Mahmoud Harizi 2, Naim Sharafi-Ahvazi 1, Reza Afrisham 2

1 Member of Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
2 Member of Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Health Research Institute, Research Center of Thalassemia & Hemoglobinopathy, Department of Immunology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: *Corresponding author: Majid Asadi-Samani, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shharekord, Iran. , Email: biology_2011@yahoo.com

Abstract

Introduction: Celery (Apium graveolens) belongs to the Umbelliferae family, and has a plenty of nutritional and pharmaceutical applications. The presence of phytoestrogenic compounds has been reported in this plant. These compounds may affect the pituitary-gonad axis. The aim of the present study was to evaluate the efficacy of hydro-alcoholic extracts of celery leaves on serum levels of testosterone, LH and FSH in male rats.

Methods: In this experimental study, 32 male Wistar rats were divided into four groups, eight rats included in each. The control group did not receive any treatment. The placebo group received distilled water and the case groups received 200 and 300 mg/kg/B.W of hydro-alcoholic celery leaf extract for 20 consecutive days by oral administration. After completion of the treatment, the rats were anesthetized and blood sampling from their heart was carried out. Then, serum levels of testosterone, LH and FSH were measured using immunoassay methods. The obtained data were analyzed by the SPSS using the statistical ANOVA test.

Results: The level of LH in the case group receiving 200 mg/kg B.W of celery extract showed a significant decrease compared with the control and placebo groups (P<0.05). The level of FSH and testosterone in case groups did not show any significant difference in comparison with the control group (P>0.05).

Conclusion: The result of the present study shows that in the administered dose, celery extract does not have any considerable side effect on the secretion of hormones in male rats.


Implication for health policy/practice/research/medical education:

Celery (Apium graveolens) does not cause any hormonal impairment in male rats; so, as celery improves fertility, its consumption might be useful in the treatment of infertility.

Please cite this paper as: Kooti W, Ghasemi-boroon M, Ghafourian M, Asadi-Samani M, Harizi M, Sharafi-Ahvazi N, et al. The effects of celery leave extract on male hormones in rats. J HerbMed Pharmacol 2015; 4(2): 56-60.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 4053

Your browser does not support the canvas element.


PDF Download: 3020

Your browser does not support the canvas element.

EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)