Logo-jhp
J Herbmed Pharmacol. 2015;4(4): 142-148.
  Abstract View: 2983
  PDF Download: 3959

Original Article

Preparation and evaluation of the clinical efficacy and safety of tomato lotion containing lycopene 

Mohammad-Ali Shahtalebi 1, Amir-Hosein Siadat 2, Setare Karbasizade 3*

1 Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Science, Isfahan, Iran
2 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Science, Isfahan, Iran
*Corresponding Author: Email: Karbasizade@skums.ac.ir

Abstract

Introduction: Skin aging starts at around age of 30 with wrinkling and pigmentations as its mainindicators. Delay and prevention of aging is a major concern for a great number of people. Thepurpose of this research was to develop and evaluate the efficacy of an anti-wrinkle tomato lotion,consisting of 5% w/w tomato powder in an oil-in-water (O/W) emulsion.Methods: Different O/W emulsions were prepared and stability tests were done on them. Theformulation that successfully passed the stability tests, was chosen and the Solanum lycopersicumpowder was added to the oily phase of this O/W emulsion. The prepared lotion was evaluated forpharmaceutical tests. In vitro permeation studies were performed to measure permeation throughcellulose acetate membrane by diffusion cell at sink condition. In vivo trial for examination of theanti-wrinkle efficacy of lotion was done on 10 healthy women as case group compared with 10volunteers using the placebo lotion (lotion base without Solanum lycopersicum powder) as controlgroup.Results: According to the experimented results on the formulated lotion, the efficient time durationfor lotion effectiveness was 42 days. Tomato powder formulated in base of lotion significantlydecreased wrinkles. Our formulation was compatible with skin and caused no sensitivity reactionin human modelsConclusion: The Lycopene in Solanum lycopersicum in this formulation has anti-aging effect. Thisformulation might be a strong candidate for treatment of skin wrinkles.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2984

Your browser does not support the canvas element.


PDF Download: 3959

Your browser does not support the canvas element.

ePublished: 14 Oct 2015
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)