Dheeraj S. Randive
1* 
, Mangesh A. Bhutkar
1, Somnath D. Bhinge
1 , Kiran P. Shejawal
1, Poonam R. Sanap
1, Pranoti D. Patil
1, Suhas A. Mane
11 Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, India
*Corresponding Author: Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, India, Email:
randivedheeraj@gmail.com
Abstract
Introduction: The aim of the current analysis was to judge the hypoglycemic action of the phyto-extracts of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana using suitable in vitro approaches.Methods: The hypoglycemic activity of the phyto-material extracts was evaluated by employing various in-vitro methods namely glucose diffusion, amylolysis kinetics and glucose adsorption capacity.Results: The extracts of L. siceraria, C. dactylon and S. rebaudiana exhibited glucose dialysis retardation indices (GDRI) of 48.14%, 37.03% and 29.62%, respectively at 60 minutes which were reduced to 15.78%, 10.52% and 18.42%, respectively at 120 minutes. All the plant extracts used in the study adsorbed glucose and their adsorptions markedly enhanced with increase in sugar concentration.Conclusion: From the outcome of the assay it can be concluded that the extracts of L. siceraria, C. dactylon and S. rebaudiana have hypoglycemic activity as observed in various in-vitro assays. However, the beneficial actions require to be verified by adopting various in vivo techniques along with clinical trials for their efficient use as potential remedial moiety.