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J Herbmed Pharmacol. 2022;11(2): 197-203.
doi: 10.34172/jhp.2022.24

Scopus ID: 85129489668
  Abstract View: 1385
  PDF Download: 872

Original Article

Evaluation of antidiabetic, antioxidant and antilipidemic potential of natural dietary product prepared from Cyphostemma digitatum in rats’ model of diabetes

Hakam Hasan Alkhateeb 1* ORCID logo, Mohammed al-duais 2 ORCID logo

1 Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan
2 Margaret A. Gilliam Institute for Global Food Security, McGill University, Montreal, QC, Canada
*Corresponding Author: Email: hakam.k@yu.edu.jo

Abstract

Introduction: Cyphostemma digitatum has a high content of antioxidant constituents and has been employed by the traditional healers and local people of Yemen for diabetes treatment. However, scientific evidence regarding its antidiabetic efficacy is largely unknown. Accordingly, the present study aimed to confirm the treatment effects of a dietary natural product prepared from Cyphostemma digitatum (PCD) in diabetic rats.Methods: Diabetes was induced by a high-fat diet and streptozotocin (HF-STZ). PCD (1 g/kg) was given by gavage administration once a day continuously for 30 days. At the end of treatment, blood and skeletal muscle samples were collected for further analysis.Results: The antidiabetic effects of PCD were demonstrated by significant reduction (P ≤ 0.05) in the levels of serum glucose (40%), triglyceride (32%), cholesterol (53%), low-density lipoprotein (LDL) (44%), malondialdehyde (MDA) (61%) in PCD treated groups compared to the diabetic control group. Additionally, PCD treatment significantly (P ≤ 0.05) restored the decreased levels of insulin (70%) and the activities of superoxide dismutase (SOD) (57%) and reduced glutathione (GSH) (544%) when compared to that of diabetic control rats. We found that treatment with PCD for 30 days fully restored the plasmalemmal glucose transporter type 4 (GLUT4) contents, as well as the phosphorylation of phosphatidylinositol 3-kinase (PI3K) (P ≤ 0.05).Conclusion: Thus, PCD treatment can be considered a potential drug candidate for diabetes.

Cyphostemma digitatum is an alternative phytomedicine endowed with antidiabetic potentials. The mechanism probably involves its high antioxidant activity. This research shows the promising antidiabetic prospects of C. digitatum in rats. Thus, this plant might be considered a candidate for developing drugs against diabetes.
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Submitted: 11 Dec 2021
Revision: 14 Feb 2022
Accepted: 16 Feb 2022
ePublished: 01 Apr 2022
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