J Herbmed Pharmacol. 2022;11(3): 360-366.
doi: 10.34172/jhp.2022.41

Scopus ID: 85135504215
  Abstract View: 1829
  PDF Download: 806

Original Article

Dietary fiber of jicama (Pachyrhizus erosus L) tuber exerts hepatoprotective effect against high-sugar drinks in mice

Putra Santoso 1* ORCID logo, Rita Maliza 1 ORCID logo, Riski Octavian 1 ORCID logo, Rauza Sukma Rita 2 ORCID logo

1 Biology Department, Faculty of Mathematics and Natural Sciences, Andalas University, Padang West Sumatra 25163, Indonesia
2 Biochemistry Department, Faculty of Medicine, Andalas University, Padang West Sumatra 25163 Indonesia
*Corresponding Author: Email: putrasantoso@sci.unand.ac.id


Introduction: Jicama (Pachyrhizus erosus, family Fabaceae) is a potent medicinal plant. Although extensive studies report the health benefits of jicama extract, few studies have investigated the efficacy of its dietary fiber in preventing metabolic diseases, including liver disease. The present study aimed to elucidate whether dietary fiber obtained from the jicama tuber counteracts the development of liver disease induced by high-sugar drinks.

Methods: Twenty-four adult male mice (DDY strain; 2 months old with bodyweight 22-25 g) were randomized into three groups: normal drink (ND), fed with tap water and standard chow; high-sucrose drink (HSD), fed with a high-sucrose drink and standard chow; and high-sucrose drink plus standard chow with 25% jicama fiber (HSD + JF 25%). After the mice were on their respective diets for ten weeks, the following parameters were measured: body weight, liver weight, malondialdehyde (MDA), histopathological alterations, blood glucose, and serum glutamate-pyruvate transaminase (SGPT).

Results: Mice in the HSD + JF 25% group had significantly lower body weight (P < 0.01), liver weight (P<0.05), MDA (P<0.01), blood glucose (P<0.01), and SGPT (P<0.01) compared to those in the HSD group. They also had fewer histopathological alterations in the liver, as demonstrated by a lower proportion of degenerated cells and an overall lower histopathological score than those in the HSD group (P<0.05).

Conclusion: Adding jicama fiber (25% of standard chow) mitigates the increase in blood glucose and body weight and histopathological changes in the liver induced by high-sucrose drinks, showing liver protective activity.

Implication for health policy/practice/research/medical education: The present study demonstrated that supplementation of fiber extracted from jicama (P. erosus) tuber in the diet counteracts liver disease caused by a high-sugar drink in an animal model. It suggests the potential for further investigations in human subjects to determine whether jicama fiber is effective as a dietary supplement to preclude metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). Please cite this paper as: Santoso P, Maliza R, Octavian R, Rita RS. Dietary fiber of jicama (Pachyrhizus erosus L) tuber exerts hepatoprotective effect against high-sugar drinks in mice. J Herbmed Pharmacol. 2022;11(3):360-366. doi: 10.34172/jhp.2022.41.
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Submitted: 08 Jan 2022
Revision: 20 Feb 2022
Accepted: 04 Mar 2022
ePublished: 25 Jun 2022
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