J Herbmed Pharmacol. 2022;11(3): 305-319.
doi: 10.34172/jhp.2022.36

Scopus ID: 85135573172
  Abstract View: 2002
  PDF Download: 1207


Ruta montana (L.) L.: An insight into its medicinal value, phytochemistry, biological properties, and toxicity

Nesrine Benkhaira 1 ORCID logo, Saad Ibnsouda Koraichi 1 ORCID logo, Kawtar Fikri-Benbrahim 1* ORCID logo

1 Department of Microbiology, Laboratory of Microbial Biotechnology and Bioactive Molecules Department of Biology, Sciences and Technologies Faculty, Sidi Mohamed Ben Abdellah University, Morocco
*Corresponding Author: Email: kawtar.fikribenbrahim@usmba.ac.ma


Ruta montana (RM) is a medicinal and aromatic plant (MAP) used in folk medicine, especially in North Africa, to treat digestive, infectious, respiratory, neurological, gynecological, and diabetic diseases. The current work aims to review the scientifically validated ethno-medicinal usage, bioactivities and phytochemistry of RM, in order to provide data support for further investigations. Data were procured from PubMed, Scopus, Google Scholar, Web of Science, ScienceDirect, and PubChem. The present study revealed that RM could be used to manage many diseases involved in public health problems, such as diabetes, hypertension, neurological disorders, infections, reproductive system disorders, and cancer. It might also replace chemical insecticides and fungicides since it exhibits antifungal, insecticidal, and larvicidal properties. RM extracts also contain mainly coumarins and alkaloids. The volatile oil of RM is characterized by an abundance of ketone compounds and 2-undecanone as major constituents. In the case of a high-dose administration, RM infusion can cause poisoning through the oral path. Thus, in-depth in vivo pharmacological studies and clinical trials are needed to transmute the traditional applications of RM into scientific-based information.

Implication for health policy/practice/research/medical education: This review provides a detailed insight into Ruta montana (L.) L. extracts, which could be considered a potential source of biomolecules, representing new, safe, and effective agents for managing diabetes, cancer, hypertension, infectious, digestive, and respiratory disorders. Please cite this paper as: Benkhaira N, Ibnsouda Koraichi S, Fikri-Benbrahim K. Ruta montana (L.) L.: An insight into its medicinal value, phytochemistry, biological properties, and toxicity. J Herbmed Pharmacol. 2022;11(3):305-319. doi: 10.34172/ jhp.2022.36.
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Abstract View: 2003

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Submitted: 11 Feb 2022
Revision: 28 Mar 2022
Accepted: 29 Mar 2022
ePublished: 25 Jun 2022
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