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J Herbmed Pharmacol. 2023;12(4): 459-468.
doi: 10.34172/jhp.2023.43430

Scopus ID: 85173762501
  Abstract View: 686
  PDF Download: 466

Original Article

Biogenic synthesis, characterization, antibacterial and antioxidant activities of silver nanoparticles mediated from Tamarindus indica Linn fruit pulp extract

Kehinde Oluwakemi Fagbemi 1* ORCID logo, Olufunmiso Olusola Olajuyigbe 1 ORCID logo, Roger Coopoosamy 2 ORCID logo

1 Department of Microbiology, School of Science Technology, PMB 4005, Babcock University, Ilisan Remo, Ogun State, Nigeria
2 Department of Nature Conservation, Faculty of Natural Science, Mangosuthu University of Technology, P.O. Box 12363, Jacobs, 4026, Durban, South Africa
*Corresponding Author: Kehinde Oluwakemi Fagbemi, Email: olakemik4u.kf@gmail.com

Abstract

Introduction: Due to the numerous potentials discovered from biologically synthesized silver nanoparticles (SNPs), the interest of many researchers has been stirred up. Tamarindus indica fruit has many therapeutic potentials attributed to fruit. Hence, the objective of this study was to synthesize, characterize, and evaluate the in vitro antioxidant and antibacterial activities of SNPs mediated from T. indica fruit pulp extract.

Methods: The bioreduction of silver nitrate was performed using methanol extract of T. indica fruit pulp. UV–vis spectrophotometry studies at 480 nm confirmed the synthesis of SNPs. The synthesized nanoparticles were characterized using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDX). The antioxidant properties were assessed using methods of ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The antibacterial potential was evaluated using the agar well technique.

Results: FTIR spectroscopy revealed that the presence of various functional groups was responsible for reduction and stabilization during the biosynthesis process. With the aid of ImageJ software, the size of the nanoparticles was determined to be in the range of 18-50 nm. The anti-oxidation activity assays showed a strong reducing potential towards the radicals tested. Lastly, strong antibacterial activities were observed when the nanoparticles were tested on some pathogenic bacteria through the agar well method.

Conclusion: This biological method of synthesizing SNP from T. indica has shown significant enhancement in its biological activities in terms of antibacterial and antioxidant properties; thus, it might be considered a therapeutic agent.


Implication for health policy/practice/research/medical education:

The synthesized SNPs mediated from T. indica showed significant radical scavenging potentials and a strong inhibitory effect on some pathogenic organisms. This study can be expanded to include an in vivo assay to acquire robust evidence on the effectiveness of SNP mediated from this fruit in the biological environment. The findings could be used as an alternate solution to herbal medicine to treat oxidative stress-related health issues and for the production of antibiotics.

Please cite this paper as: Fagbemi KO, Olajuyigbe OO, Coopoosamy R. Biogenic synthesis, characterization, antibacterial and antioxidant activities of silver nanoparticles mediated from Tamarindus indica Linn fruit pulp extract. J Herbmed Pharmacol. 2023;12(4):459-468. doi: 10.34172/jhp.2023.43430.

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Submitted: 13 Apr 2022
Revision: 29 Jun 2022
Accepted: 30 Jun 2022
ePublished: 10 Aug 2023
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