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J Herbmed Pharmacol. 2023;12(1): 159-167.
doi: 10.34172/jhp.2023.16

Scopus ID: 85147748255
  Abstract View: 778
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Original Article

Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats

Scholastica O. Anadozie 1* ORCID logo, Olusola B. Adewale 1 ORCID logo, Oluwole B. Akawa 2,3 ORCID logo, Juliet N. Olayinka 4 ORCID logo, Olukemi A. Osukoya 1 ORCID logo, Margaret M. Umanah 1 ORCID logo, Oyindamola A. Olaoye 1 ORCID logo, Oluwatosin S. Oludoro 5 ORCID logo

1 Biochemistry Program, Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Nigeria
2 Department of Pharmacology and Toxicology, College of Pharmacy, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Nigeria
3 Molecular Biocomputation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa
4 Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Nigeria
5 Chemistry Program (Environmental Chemistry), Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Nigeria
*Corresponding Author: Scholastica O. Anadozie, Email: anadozieso@abuad.edu.ng; , Email: scholanad2019@gmail.com

Abstract

Introduction: Mondia whitei (Hook.f.) Skeels is rich in antioxidant activity and is known for its nutritional and medicinal uses. This study evaluated the protective effect of M. whitei fruit against cadmium-induced hepatic damage in rats.

Methods: Twenty-five albino (Wistar strain) rats were randomly assigned into five equal groups. Rats in group I served as control, rats in group II were intoxicated with 5 mg/kg body weight (b.w.) cadmium chloride (CdCl2 ) for 5 days via an oral route, while groups III, IV, and V were respectively administered with 5 mg/kg b.w. CdCl2 for 5 days co-treated with 70 mg/kg b.w silymarin, 250 and 500 mg/kg b.w. of aqueous fruit extract of M. whitei (AEMW) for 7 days.

Results: Cadmium caused a significant (P<0.05) increase in the concentration of cadmium in the liver as well as liver function markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin. In addition, a significant (P<0.05) elevation in the level of malondialdehyde (MDA) and a reduction in the nitric oxide (NO) and antioxidant status were noted in the CdCl2 -exposed rats; hepatic degeneration and congested portal area were also noted. These changes were, however, reduced in the cadmium-intoxicated rats co-treated with silymarin, 250 mg/kg or 500 mg/kg AEMW.

Conclusion: Our result suggests that AEMW exerts protective effects against CdCl2 -induced hepatic damage in rats, and this might be due to the presence of phytochemicals in the plant capable of scavenging oxidative stress caused by cadmium.


Implication for health policy/practice/research/medical education:

Mondia whitei protects against cadmium-induced hepatoxicity and might be beneficial in these patients.

Please cite this paper as: Anadozie SO, Adewale OB, Akawa OB, Olayinka JN, Osukoya OA, Umanah MM, et al. Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats. J Herbmed Pharmacol. 2023;12(1):159- 167. doi: 10.34172/jhp.2023.16.

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Submitted: 08 Jun 2022
Revision: 07 Aug 2022
Accepted: 10 Aug 2022
ePublished: 31 Dec 2022
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