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J Herbmed Pharmacol. 2023;12(1): 135-146.
doi: 10.34172/jhp.2023.13

Scopus ID: 85147740743
  Abstract View: 836
  PDF Download: 583

Original Article

Influence of anti-hyperlipidemic activity by co-administration of polyamines and rutin with simvastatin

Rajesh R Patil 1* ORCID logo, Manoj K Aswar 2 ORCID logo, Satish B Bhise 1 ORCID logo, Suresh R Naik 1 ORCID logo

1 Department of Pharmacology, Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (Bk.), Lonavala, Pune 411 401, (MS) India
2 Department of Pharmacology, Rajarshi Shahu College of Pharmacy, Buldana-443001(MS), India
*Corresponding Author: Rajesh R Patil, Email: rajeshpatil11@gmail.com

Abstract

Introduction: Natural polyphenols, rutin, endogenous polycations, and polyamines (spermine and spermidine) are reported to have beneficial effects on hyperlipidemia, obesity, and cardiovascular disease (CVD). The present study attempts to evaluate the combined effects of polyamines or rutin and simvastatin on hyperlipidemic rats.

Methods: Wistar rats were maintained on a high-fat diet (HFD) for 60 days. The HFD rats were administered from the 31st day onward with polyamines (PAs), rutin, and simvastatin for the next 30 days. The body weight, serum lipid profile, biomarkers, liver cholesterol, triglycerides, hydroxymethylglutaryl-CoA (HMG-CoA) reductase activity, antioxidants, and marker enzymes in HFD rats were estimated along with the liver histoarchitecture of the rats.

Results: The experimental findings demonstrated abnormal alterations in body weight, serum lipid profile, hepatic lipid, and HMG-CoA reductase activity, hepatic antioxidants, serum marker enzymes, blood glucose, total protein, and histoarchitecture of the liver in HFD rats. The aforementioned treatment elicited a significant reduction in the biochemical parameters, biomarkers, and the evaluated enzymes in the present study. Furthermore, an improvement in the histoarchitecture of the liver was observed.

Conclusion: The experimental results point out the positive role of antioxidant polyamines along with rutin on different parameters in HFD rats. Thus the combinatorial effect of polyamines and rutin with simvastatin (5 mg/kg) was found to be greater than simvastatin (10 mg/kg) alone. The enhancement in the anti-hyperlipidemic effect of simvastatin may be due to the intrinsic antioxidant property of polyamines and rutin.


Implication for health policy/practice/research/medical education:

Rutin, a polycationic polyamine and flavonoid, has been shown to have strong antioxidant activity and improve lipid metabolism. Hence, it is suggested that polyamines and rutin be used as adjuvants alongside clinically used anti-hyperlipidemic agents to improve their therapeutic efficacy.

Please cite this paper as: Patil RR, Bhise SB, Aswar MK, Naik SR. Influence of anti-hyperlipidemic activity by co-administration of polyamines and rutin with simvastatin. J Herbmed Pharmacol. 2023;12(1):135-146. doi: 10.34172/jhp.2023.13.

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Submitted: 19 Aug 2022
Revision: 08 Oct 2022
Accepted: 09 Oct 2022
ePublished: 31 Dec 2022
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