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J Herbmed Pharmacol. 2023;12(2): 250-261.
doi: 10.34172/jhp.2023.27

Scopus ID: 85158163729
  Abstract View: 1126
  PDF Download: 770

Original Article

The modulatory effects of black chia (Salvia hispanica) and garden cress (Lepidium sativum) seeds on Nε-CML formation in streptozotocin-injected rats

Hadeer Saad Mohamed ORCID logo, Tahany El-Sayed Kholief ORCID logo, Radwa Wahid Mohamed* ORCID logo, Amira Abd El-Rhman ORCID logo

1 Department of Biochemistry and Nutrition, Faculty of women for Art, Science and Education, Ain Shams University, Egypt
*Corresponding Author: Radwa Wahid Mohamed, Email: radwa.wahid@women.asu.edu.eg

Abstract

Introduction: Antioxidant and hypoglycemic properties of some plant seeds are considered natural preventives for diabetic-associated glycation. This study is concerned with the evaluation of the bioactive components of black chia and garden cress seeds and the examination of their modulatory effects on hyperglycemia and associated glycation induced by streptozotocin (STZ) injection.

Methods: Forty male rats were divided into 4 groups, 10 rats each: Group 1 (healthy control group); group 2 (diabetic group): rats injected STZ intraperitoneally to induce hyperglycemia; group 3 and group 4: rats treated (after diabetic induction) with 1 mL (20% w/w) black chia and garden cress seed extract, respectively.

Results: STZ injection caused marked hyperglycemia, oxidative stress, glycation, and inflammation condition with disturbance in organs functions and structural alterations in pancreatic tissue, while; treatment with black chia and garden cress seed extracts showed remarkable (P<0.05) modulatory effects on hyperglycemia and associated disorders.

Conclusion: Black chia and garden cress seeds might be used in the management of diabetes and associated glycation.


Implication for health policy/practice/research/medical education:

The use of black chia and garden cress seeds improves lesions of hyperglycemia and reduces the related side effects. These seeds might be recommended to physicians for the treatment of diabetes.

Please cite this paper as: Mohamed HS, Kholief TE, Mohamed RW, Abd El-Rhman A. The modulatory effects of black chia (Salvia hispanica) and garden cress (Lepidium sativum) seeds on Nε-CML formation in streptozotocin-injected rats. J Herbmed Pharmacol. 2023;12(2):250-261. doi: 10.34172/jhp.2023.27.

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Submitted: 11 Oct 2022
Revision: 10 Dec 2022
Accepted: 10 Jan 2023
ePublished: 18 Mar 2023
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