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J Herbmed Pharmacol. 2023;12(2): 233-240.
doi: 10.34172/jhp.2023.25

Scopus ID: 85158092839
  Abstract View: 649
  PDF Download: 433

Original Article

Protective effect of almond oil and primrose oil on neurochemical and lipid profile in ovariectomized rats

Eman Hassan Abdel Aziz Sharaf* ORCID logo, Enas Ali Kamel, Marwa Mosaad. Hassan ORCID logo

1 Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
*Corresponding Author: Eman Hassan Abdel Aziz Sharaf, Email: Eman.Sharaf@women.asu.edu.eg

Abstract

Introduction: Ovariectomies rats were used to assess the preventive effects of almond and primrose oils on their lipid and neurochemical profiles.

Methods: The experimental groups were as follows: Group 1: A negative control group. Group 2: Rats given an oral dose of almond oil (800 mg/kg/d) for 30 days. Group 3: Rats given an oral dose of primrose oil (500 mg/kg/d) for 30 days. Group 4: Untreated ovariectomized rats. Group 5: Ovariectomized rats given an oral dose of almond oil (800 mg/kg/d) for 30 days. Group 6: Ovariectomized rats given an oral dose (500 mg/kg/d) of primrose oil daily for 30 days.

Results: Oral administration of almond and primrose oils significantly decreased mean (P<0.05) serum total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) concentrations and raised high-density lipoprotein cholesterol (HDL-C) in the ovariectomized groups compared to group 4 (P<0.05). They also increased leptin and estradiol (E2) concentrations in groups 5 and 6. Administration of oils showed a marked increase in noradrenalin, dopamine, and 5-hydroxytyramin levels and a marked decrease in PGE2 and COX-2 levels (P<0.05). Rats given almond and primrose oils revealed minor capillary congestion in the hippocampus in brain sections.

Conclusion: Administration of almond or primrose oils may improve central nervous system functions and decrease the risk of cardiovascular illnesses. They also might be effective against atherosclerosis, inflammation, endocrine disorders, and cognitive impairments for women who undergo surgical menopause prior to their natural menopause.


Implication for health policy/practice/research/medical education:

Almond and primrose oils improved the lipid and neurochemical parameters in ovariectomized rats and ameliorated the histological changes in the rat hippocampal brain tissue. These essential oils might be recommended to physicians as for the treatment of cardiovascular disorders and mood and memory defects in ovariectomized women.

Please cite this paper as: Sharaf EH, Kamel EA, Hassan MM. Protective effect of almond oil and primrose oil on neurochemical and lipid profile in ovariectomized rats. J Herbmed Pharmacol. 2023;12(2):233-240. doi: 10.34172/jhp.2023.25.

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Submitted: 16 Nov 2022
Revision: 16 Dec 2022
Accepted: 31 Dec 2022
ePublished: 18 Mar 2023
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