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J Herbmed Pharmacol. 2023;12(4): 492-499.
doi: 10.34172/jhp.2023.44843

Scopus ID: 85173638379
  Abstract View: 1255
  PDF Download: 842

Original Article

Anti-atherosclerotic effects of Camellia chrysantha and Gynostemma pentaphyllum extracts mixture

Hong Hanh Nguyen 1 ORCID logo, Ngan Hoang Nguyen 2 ORCID logo, Tu Thi Thanh Nguyen 3* ORCID logo

1 Department of Geriatric, E Hospital, 87-89 Tran Cung Street, Cau Giay District, Hanoi, Vietnam
2 Department of Pharmacology, Vietnam Military Medical University (VMMU), 160 Phung Hung Street, Ha Dong District, Hanoi, Vietnam
3 Faculty of Traditional Medicine, Hanoi Medical University, 01 Ton That Tung Street, Dong Da District, Hanoi, Vietnam
*Corresponding Author: Tu Thi Thanh Nguyen, Email: thanhtu@hmu.edu.vn

Abstract

Introduction: The combination Camellia chrysantha and Gynostemma pentaphyllum is used in Vietnam against hyperlipidemia. This study aims to evaluate the effects of the extract mixture of C. chrysantha and G. pentaphyllum in the atherosclerosis-induced rat model.

Methods: Rats were administered with the extract mixture of C. chrysantha and G. pentaphyllum daily (7 and 14 g/kg/day) for 8 weeks upon the start of the study while they were simultaneously put on an atherosclerosis-induced diet. Blood samples were taken to examine the blood lipid indicators of the rats in the beginning, after 4 and 8 weeks of the study, respectively. After 8 weeks of treatment, the rats’ livers were removed to assess their overall health and the atherosclerosis patterns of their abdominal arteries.

Results: The mixture of leaf extracts of C. chrysantha and G. pentaphyllum in the doses of 7 and 14 g/kg/day reduced blood lipid indices, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels and the atherogenic index (AI). Furthermore, this mixture also increased the levels of high-density lipoprotein cholesterol (HDL-C) in the blood, decreased the incidence of liver fat, and prevented the development of atherosclerotic lesions in the abdominal aorta in the rats.

Conclusion: These results indicate that a mixture of C. chrysantha and G. pentaphyllum has a potential in preventing and treating atherosclerosis


Implication for health policy/practice/research/medical education:

Our findings revealed that an extract mixture of C. chrysantha and G. pentaphyllum could reduce blood lipid indices and increase HDL-C levels in the rat atherosclerotic blood, indicating that this mixture is a potential source of natural agents for atherosclerosis treatment.

Please cite this paper as: Nguyen HH, Nguyen HN, Nguyen TTT. Anti-atherosclerotic effects of Camellia chrysantha and Gynostemma pentaphyllum extracts mixture. J Herbmed Pharmacol. 2023;12(4):492-499. doi: 10.34172/jhp.2023.44843

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Submitted: 08 Feb 2023
Revision: 07 Jul 2023
Accepted: 10 Jul 2023
ePublished: 10 Aug 2023
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