J Herbmed Pharmacol. 2023;12(3): 419-424.
doi: 10.34172/jhp.2023.46

Scopus ID: 85164919353
  Abstract View: 760
  PDF Download: 416

Original Article

Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats

Bandana Rath 1 ORCID logo, Lalit Mohan Sika 1 ORCID logo, Ikhita Misra 2 ORCID logo, Snigdha Rani Panigrahy 3* ORCID logo, Baidyanath Mishra 1 ORCID logo

1 Department of Pharmacology, SLN MCH, Koraput, Odisha, India
2 Department of ENT, SJMCH, Puri, Odisha, India
3 Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India
*Corresponding Author: Snigdha Rani Panigrahy, Email: sweetsnigdha64@gmail.com


Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder, basically manifested by motor symptoms. However, there are other associated non-motor features in PD, including depression, anxiety, and cognitive impairments that significantly affect the quality of life. Scientific reports have shown that Sargassum wightii, a brown seaweed, protects against rotenone-induced motor deficits, mitochondrial dysfunction, and oxidative stress in rats. We therefore, undertook this study to evaluate its efficacy in alleviating rotenone-induced non-motor symptoms such as anxiety-like behavior and cognitive deficits in rats.

Methods: Rotenone at a dose of 10 mg/kg was given orally for 28 days to induce PD model in male rats. The vehicle and the test drug were given orally daily, 1 hour prior to the rotenone administration. The protective effect of S. wightii (methanol extract at 400 mg/kg dosage) was assessed through an array of tests: Elevated plus maze test, Morris water maze test, and novel object recognition test. On the 28th day, the rats were sacrificed, and hippocampal neurobiochemical analyses were performed using high-performance liquid chromatography (HPLC).

Results: Co-administration of S. wightii reversed the rotenone-induced anxiety-like behavior and cognitive deficits to a significant extent (P<0.001). It also restored the hippocampal neurotransmitters (5-hydroxytryptamine, dopamine, and 5-hydroxy indole acetic acid) significantly (P<0.001).

Conclusion: Sargassum wightii provides neuroprotective effects and reduces the non-motor symptoms of PD. Therefore, it might be a novel insight into PD therapy.

Implication for health policy/practice/research/medical education:

The present research explains the scientific basis of neuroprotective activity of Sargassum wightii against the non-motor symptoms of PD, such as anxiety-like behavior and cognitive deficits. Therefore, this extract can be a potential candidate in herbal formulations as a neuroprotectant against PD.

Please cite this paper as: Rath B, Sika LM, Misra I, Panigrahy SR, Mishra BN. Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats. J Herbmed Pharmacol. 2023;12(3):419-424. doi: 10.34172/jhp.2023.46.

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Submitted: 17 Feb 2023
Revision: 01 Apr 2023
Accepted: 02 Apr 2023
ePublished: 01 Jun 2023
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