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J Herbmed Pharmacol. 2023;12(4): 560-566.
doi: 10.34172/jhp.2023.46064

Scopus ID: 85173787890
  Abstract View: 808
  PDF Download: 953

Original Article

Antibacterial efficacy of curcumin, allicin, gingerol and cinnamon against Enterococcus faecalis: An in vitro study

Vijayaragavan Haripriya 1 ORCID logo, Sekar Mahalaxmi 2 ORCID logo, Sampath Vidhya 2* ORCID logo, Pranav Vanajassun Purushothaman 3 ORCID logo

1 Private practitioner, Tirupati, India
2 Department of Conservative Dentistry and Endodontics, SRM Dental College, SRM Institute of Science and Technology, Ramapuram, Bharathi Salai, Chennai 600089, TN, India
3 Specialist Dentist Endodontist, Al Kindi Hospital, Kingdom of Bahrain
*Corresponding Author: Sampath Vidhya, Email: , Email: vidhyas@srmist.edu.in

Abstract

Introduction: Bioactive compounds from plants have potential antimicrobial activity. The aim of this in vitro study was to evaluate the antimicrobial efficacy of curcumin, allicin, gingerol and cinnamon compared to 4% sodium hypochlorite (NaOCl) against Enterococcus faecalis and its biofilm.

Methods: The dry herbal compounds were diluted with dimethyl sulfoxide (DMSO). Antimicrobial activity was evaluated using agar diffusion test, minimum inhibitory concentration (MIC) assay, minimum bactericidal concentration (MBC) test, time kill study, and biofilm susceptibility assay. The zone of inhibition (ZOI) was determined using agar diffusion test on Muller Hinton (MH) agar plates. MIC was evaluated using the tube dilution method. Root canals of extracted human anterior teeth were instrumented, split into two halves, autoclaved, and incubated with brain heart infusion broth containing E. faecalis for 21 days to form a biofilm. The susceptibility of the biofilm to the test solutions was evaluated by counting bacterial colonies on MH agar.

Results: NaOCl exhibited potent antimicrobial activity under all tested parameters. Allicin showed a significantly greater ZOI, while curcumin showed the least MIC among the tested herbal extracts (P<0.05). MBC varied widely among the groups with no significant difference between allicin and cinnamon (P>0.05). Gingerol and cinnamon were significantly superior to the other groups killing E. faecalis within 4-4.2 min (P<0.05). Curcumin, gingerol, and cinnamon were equally efficacious as NaOCl in completely eradicating E. faecalis biofilm (P>0.05).

Conclusion: NaOCl emerged as the most efficacious antibacterial agent and all herbal extracts showed significant antibacterial activity against E. faecalis.


Implication for health policy/practice/research/medical education:

This in vitro study showed the promising antibacterial effects of curcumin, allicin, gingerol, and cinnamon against Enterococcus faecalis. Future studies should focus on harnessing the advantages of these natural medicaments in endodontic disinfection.

Please cite this paper as: Haripriya V, Mahalaxmi S, Vidhya S, Purushothaman PV. Antibacterial efficacy of curcumin, allicin, gingerol and cinnamon against Enterococcus faecalis: An in vitro study. J Herbmed Pharmacol. 2023;12(4):560-566. doi: 10.34172/ jhp.2023.46064.

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Submitted: 15 Apr 2023
Revision: 21 Jun 2023
Accepted: 28 Jun 2023
ePublished: 10 Aug 2023
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