J Herbmed Pharmacol. 2024;13(2): 260-268.
doi: 10.34172/jhp.2024.49325

Scopus ID: 85192253418
  Abstract View: 297
  PDF Download: 200

Original Article

Anticancer activity of silver nanoparticles synthesized from aqueous leaf extract of Solanum trilobatum (Purple fruit pea eggplant) on human oral cancer cells

Anuradha Ganesan 1* ORCID logo, Gautham Kumar N 2 ORCID logo, Prabhu Manickam Natarajan 3,4,5 ORCID logo

1 Department of Oral Medicine & Radiology, SRM Dental College, Bharathi Salai, Chennai-89, India
2 Department of Periodontics, Madha Dental College & Hospital, Kundrathur, Chennai-69, India
3 Department of Periodontics College of Dentistry, Ajman University, Ajman, UAE
4 Department of Clinical Sciences, Ajman University, Ajman, UAE
5 Center of Medical and Bio-allied Health Sciences and Research, Ajman University, Ajman, UAE
*Corresponding Author: Anuradha Ganesan,, Email: anug77@yahoo.com


Introduction: This research explores the capability of silver nanoparticles (AgNPs) produced via friendly methods by using Solanum trilobatum leaf extract. The choice of S. trilobatum was supported by its diverse phytochemical makeup, which comprises recognized bioactive elements known for their anti-inflammatory and anti-cancer attributes. This research explores the effect of AgNPs derived from this plant as a promising eco-friendly strategy in oral cancer treatment.

Methods: The synthesis of AgNPs involved employing S. trilobatum leaf extract, with observable color changes and spectral analyses confirming the unique characteristics of the nanoparticles. Fourier transform infrared spectroscopy detected distinct functional groups, whereas scanning electron microscopy (SEM) confirmed the presence of biocapped nanoparticles exhibiting various shapes and sizes spanning from 100 to 300 nm.

Results: Cytotoxicity assessments via the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay revealed a half-minimal inhibitory concentration (IC50) value of 3.715 ± 0.242 μg/mL against the oral cancer (KB) cell line, indicating a significant inhibition. Acridine orange/ethidium bromide (AO/EtBr) and reactive oxygen species (ROS) assays further supported the AgNPs’ anti-cancer potential, affirming their promise for oral cancer therapy.

Conclusion: AgNPs synthesized from S. trilobatum leaf extract showed substantial potential as a therapeutic agent for oral cancer. This research adds to the increasing evidence endorsing the use of environmentally friendly synthesized nanoparticles in medical treatments.

Implication for health policy/practice/research/medical education:

Findings from this study unveiled the prospective significance of eco-friendly synthesis, employing silver nanoparticles derived from Solanum trilobatum leaf extract, showcasing its promise as a safe and potent anti-cancer agent without notable toxicity concerns for future applications.

Please cite this paper as: Ganesan A, Kumar NG, Natarajan PM. Anticancer activity of silver nanoparticles synthesized from aqueous leaf extract of Solanum trilobatum (Purple fruit pea eggplant) on human oral cancer cells. J Herbmed Pharmacol. 2024;13(2):260-268. doi: 10.34172/jhp.2024.49325.

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Submitted: 24 Oct 2023
Accepted: 25 Dec 2023
ePublished: 01 Apr 2024
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