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J Herbmed Pharmacol. 2024;13(3): 482-490.
doi: 10.34172/jhp.2024.51515
  Abstract View: 704
  PDF Download: 95

Original Article

Investigation of hypoglycemic and antidiarrheal activity on mice model and in vitro anthelmintic study of Macropanax dispermus (Blume) Kuntze (Araliaceae): a promising ethnomedicinal plant

Syeda Rubaiya Afrin 1 ORCID logo, Mohammad Rashedul Islam 1 ORCID logo, Sayeda Saima Didari 1 ORCID logo, Sarah Waddun Jannat 1 ORCID logo, Ummah Tasnim Nisat 1,2 ORCID logo, Mohammed Kamrul Hossain 1* ORCID logo

1 Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
2 Department of Pharmacy, University of Science and Technology, Chittagong, Bangladesh
*Corresponding Author: Mohammed Kamrul Hossain, Email: mkhossain73@yahoo.com, Email: mkhossain19732017@gmail.com

Abstract

Introduction: Macropanax dispermus is an ethnomedicinal plant, which has been shown to have pharmacological effects against inflammation. Inflammation is also associated with diabetic-related complications. In addition, the indigenous people used this plant to cure numerous digestive system disorders. These ethnomedicinal uses have inspired the current research to focus on determining the biological potential of the crude methanol extract of its leaves (MDML) and stem barks (MDMS) against morbid diseases such as diarrhea, helminthiasis, and diabetes mellitus related to hyperglycemia. This study also identified the functional groups present in MDML which could correlate the presence of different phytochemicals responsible for biological activities.

Methods: The hypoglycemic activity and antidiarrheal tests were done on Swiss albino mice through an oral glucose tolerance test (OGTT) and castor-oil-induced diarrhea, respectively. The anthelmintic test was done in vitro on Pheretima posthuma. The functional groups were identified by using Fourier-transform infrared (FTIR) spectroscopy.

Results: Here, MDML at 400 mg/kg exhibited a significant (P<0.05) hypoglycemic activity as well as decreased diarrheal drops significantly (P<0.001) when compared to the control group. Additionally, MDMS showed a concentration-dependent significant effect as a prospective anthelmintic agent. The FTIR spectra demonstrated the presence of different functional groups, which might contribute to the presence of flavonoids, saponins, terpenoids, and other related compounds.

Conclusion: The present research demonstrated that MDML and MDMS might be effective interventions for treating hyperglycemia, diarrhea, and helminthiasis.


Implication for health policy/practice/research/medical education:

The investigated Macropanax dispermus (Blume) Kuntze (Araliaceae) extracts exhibited significant activity against hyperglycemia and castor oil-induced diarrhea and might contribute to the formulation of alternative medicinal agents to treat diabetes and diarrhea. In addition, MDMS was proved to be an effective anthelmintic agent.

Please cite this paper as: Afrin SR, Islam MR, Didari SS, Jannat SW, Nisat UT, Hossain MK. Investigation of hypoglycemic and antidiarrheal activity on mice model and in vitro anthelmintic study of Macropanax dispermus (Blume) Kuntze (Araliaceae): a promising ethnomedicinal plant. J Herbmed Pharmacol. 2024;13(3):482-490. doi: 10.34172/jhp.2024.51515.

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Submitted: 23 Mar 2024
Accepted: 11 Jun 2024
ePublished: 27 Jun 2024
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