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J Herbmed Pharmacol. 2024;13(2): 300-307. doi: 10.34172/jhp.2024.49406

Original Article

Solanum trilobatum leaf extract-derived silver nanoparticles downregulate the PI3K/AKT/mTOR signaling pathway and attenuate oral squamous cell carcinoma cell proliferation

Anuradha Ganesan 1 * ORCID, Gautham Kumar N 2 ORCID, Prabhu Manickam Natarajan 3,4,5 ORCID

Cited by CrossRef: 1


1- El‐Tayeb M, E. Ahmed M, S. Alkhattaf F, Alhomaidi E, Sakayanathan P. Artemisia pallens‐Mediated Manganese Nanoparticles: Apoptotic Effects on Human Epidermoid Carcinoma Cells and Their Antibiofilm Properties. Microscopy Res & Technique. 2025;88(12):3211 [Crossref]
2- K, V, S, N, A. Green Synthesis of Multiscale Polymeric (Starch/Pva/Cuo-Nps) Electrospun Nanofibers from Ectocarpales (Marine Macroalgae) Extract: Physicochemical Characterization And Wound Healing Assessment on Hacat Cells . PJS. 2026;16(4S):856 [Crossref]
3- K, V, S, S, A, A. Sustainable Fabrication of Polymeric Electrospun Nanoscaffolds Embedded with Green Synthesized Cuo Nanoparticles from Ectocarpales Extract for Enhanced Cytotoxicity and Antioxidant Activity. PJS. 2026;16(4S):901 [Crossref]
4- K, V, P, N, A. Anti-Inflammatory Activity of Ultrasound-Mediated Green Synthesis of Cuo Nanoparticles using Ectocarpales (Marine Macroalgae) Extract and their Integration into Starch/Pva Electrospun Nanofibers . PJS. 2026;16(4S):886 [Crossref]
5- Gan Y, Li D, Xu H, Han S, Zhu H, Wei Z, Cai Z, Huang J. The PI3K/AKT/mTOR Pathway and Oral Diseases: A Bibliometric Analysis From 2008 to 2025. Clinical & Exp Dental Res. 2025;11(5) [Crossref]
6- Kumarasamy R, Natarajan P, Mathivanan I, Balasubramaniam M, SN S, Prabhu D, Raju K, Mironescu M, Mironescu I. Sustainable biogenic synthesis of silver nanoparticles for oral cancer: a comprehensive review. Front Nanotechnol. 2026;7 [Crossref]
7- K, V, S, N, A. Green Synthesized Copper Oxide Nanoparticles Incorporated with Starch Polyvinyl Alcohol Electrospun Nanoscaffolds Exhibit Enhanced Antimicrobial Activity . PJS. 2026;16(4S):880 [Crossref]