J Herbmed Pharmacol. 2020;9(1): 61-67.
doi: 10.15171/jhp.2020.09

Scopus ID: 85103089954
  Abstract View: 2803
  PDF Download: 1716

Original Article

Effects of gallic acid on rat testopathy following morphine administration: an experimental study

Cyrus Jalili 1 ORCID logo, Amir Abdolmaleki 2 ORCID logo, Shiva Roshankhah 2 ORCID logo, Mohammad Reza Salahshoor 2* ORCID logo

1 Medical Biology Research Center, Department of Anatomical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: *Corresponding author: Mohammad Reza Salahshoor, Email:, Email: reza.salahshoor@yahoo.com


Introduction: Morphine (MOR) as a psychoactive agent in the opium family causes free radicals accumulation which leads to failure in spermatogenesis. Gallic acid (GA), a polyphenolic acid, is found in various plants with antioxidant, anti-fungal, anti-viral, and anti-allergic activities. The purpose of this study was to evaluate the effects of GA against MOR-induced damage to the reproductive parameter of rats.

Methods: Sixty-four male Wistar rats (8 weeks, 220-250 g) were categorized into 8 groups by random (n=8/each); normal control and MOR control groups; GA groups (5, 10, 20 mg/kg) and MOR + GA groups (5, 10, 20 mg/kg). Treatments were administered intraperitoneally (i.p), daily for 4 weeks. The sperm parameters, spermatogenesis index (SI), total antioxidant capacity, testosterone level, and seminiferous tube diameter (STD) were assessed.

Results: All sperm parameters reduced significantly in the MOR control group than to the normal control group (P < 0.01). All parameters were significantly improved in GA and GA + MOR treatment groups compared to the MOR control group (P < 0.01).

Conclusion: MOR caused a detrimental effect on male reproductive parameters. Also, no significant modifications were observed in all doses of GA treatments in comparison with the normal control group. GA compensates the toxic effect of MOR on reproductive parameters. Hence, GA administration is beneficial in MOR users.

Implication for health policy/practice/research/medical education:

Gallic acid can significantly reduce the morphine related damages in male reproductive parameters through antioxidant properties. Hence, its consumption is recommended in morphine consumers.

Please cite this paper as: Jalili C, Abdolmaleki A, Roshankhah SH, Salahshoor MR. Effects of gallic acid on rat testopathy following morphine administration: an experimental study. J Herbmed Pharmacol. 2020;9(1):61-67. doi: 10.15171/jhp.2020.09.

First Name
Last Name
Email Address
Security code

Abstract View: 1276

Your browser does not support the canvas element.

PDF Download: 1716

Your browser does not support the canvas element.

Submitted: 01 Jun 2019
Accepted: 03 Sep 2019
ePublished: 17 Jan 2022
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)