Logo-jhp
J Herbmed Pharmacol. 2021;10(2): 194-201.
doi: 10.34172/jhp.2021.21

Scopus ID: 85103673180
  Abstract View: 2427
  PDF Download: 1089

Original Article

Amelioration of oxidative stress, inflammation and liver function by nutraceuticals in rat model of hepatic cancer initiation induced by N-nitrosodiethylamine

Sahar Y. Al-Okbi 1* ORCID logo, Doha A. Mohamed 1 ORCID logo, Hagar F.H. Elbakry 1 ORCID logo

1 Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt
*Corresponding Author: Email: S_Y_alokbi@hotmail.com

Abstract

Introduction: Nutraceuticals might serve as protective agent against liver cancer induced by pro-cancerous chemicals that initiate high oxidative stress, inflammation and affect DNA integrity. The aim of the present research was to study the prevention of hepatocellular carcinoma initiation induced by N-nitrosodiethylamine (NDEA) through treatment by nutraceuticals.

Methods: Two nutraceuticals were prepared; the first (NI) was a mixture of different extracts of green tea, wheat germ and tomato, the second one (NII) was composed of extracts mixture of broccoli, hazelnuts and carrot. Total flavonoids and flavonols were determined in the nutraceuticals. Four groups of rats were run; the first served as control normal, the other three groups were treated by intraperitoneal injection of NDEA, one of these groups was designated as control NDEA, the other two groups (test groups) were treated daily with oral doses of NI and NII, respectively. The experiment continued for 8 weeks. Plasma transaminases, alkaline phosphatase and catalase activities, total protein, albumin, malondialdehyde (MDA) and tumor necrosis factor-α (TNF-α) along with liver MDA level and catalase activity were assessed.

Results: NI showed higher flavonoids and lower flavonols than NII (P < 0.05). High oxidative stress and inflammation biomarkers, liver dysfunction, reduced plasma albumin and total protein were demonstrated in control NDEA compared to control normal (P < 0.05). Test groups showed significant improvement in all parameters (P < 0.05) compared to NDEA control. NI was superior in improving plasma transaminases and catalase activities, MDA and TNF-α levels and liver catalase activity compared to NII (P < 0.05).

Conclusion: Both NI and NII might prevent liver cancer initiation during exposure to carcinogenic agents, NI being superior to NII.


This research showed that extract mixtures of green tea, wheat germ and tomato (NI), and broccoli, hazelnuts and carrot (NII) prevent liver cancer initiation induced by NDEA; the mechanism probably involves antioxidant and anti-inflammatory activities beside improvement of liver function. These nutraceuticals might be also used as chemotherapeutic adjunct for management of liver cancer.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2428

Your browser does not support the canvas element.


PDF Download: 1089

Your browser does not support the canvas element.

Submitted: 15 Aug 2020
Revision: 03 Jul 2020
Accepted: 04 Nov 2020
ePublished: 07 Jan 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)