J Herbmed Pharmacol. 2023;12(1): 13-24.
doi: 10.34172/jhp.2023.02

Scopus ID: 85147777105
  Abstract View: 849
  PDF Download: 936


A comprehensive review on the phytochemistry, pharmacological, ethnobotany, and traditional uses of Paeonia species

Sunil Kumar 1* ORCID logo, Kshirod Kumar Ratha 1 ORCID logo, Meda Mruthyumjaya Rao 1 ORCID logo, Rabinarayan Acharya 2 ORCID logo

1 Central Ayurveda Research Institute, Bhubaneswar, Odisha, India
2 Central Council for Research in Ayurvedic Sciences, New Delhi, India
*Corresponding Author: Sunil Kumar, Email: sunilkumarbhu08@gmail.com


Since ancient times, people have used medicinal plants as a source of medications to treat and prevent diseases. Paeonia species are important therapeutic plants in Ayurvedic, Unani, and Traditional Chinese Medicine. This study aims to provide updated information on the ethnobotany, phytochemistry, and pharmacological activities of Paeonia species discovered until now. Using the keywords “Paeonia”, “geographical distribution”, “ethnopharmacology and traditional values”, “phytochemistry”, “antioxidant”, “anti-inflammatory”, “antimicrobial”, “cardiovascular diseases”, and “anticancerous properties”, the published reports from 2001 to 2022 were retrieved using Google Scholar, Science Direct, PubMed, and Scopus databases. A total of 156 published articles were studied after meeting the qualifying criteria. Out of these, 52 articles were studied for phytochemistry, ethnopharmacological and traditional uses. Paeonia emodi is used to treat hypertension, asthma, convulsions, epilepsy, bronchitis, ascites, uterine abnormalities, and a variety of skin ailments. Bioactive compounds like triterpenes, monoterpene glucosides, phenols, tannins, emodinol, benzoic acid, paeonin A and B, steroids, several secondary metabolites like paeoniflorin and paeonol, and several minerals are abundant in the Paeonia species. In recent studies, Paeonia emodi has been shown to possess pharmacological properties like antioxidant, antibacterial, anti-inflammatory, insecticidal, and anti-tumor activities. Convincing data supports the traditional ethnomedicinal claims of the plant; the abundant phytocompounds of the plant are attributed to its broad spectrum of pharmacological activities. In order to understand the molecular mechanisms underlying the action of the bioactive ingredients in drug development processes and to investigate their potential at the clinical level, more research is required.

Implication for health policy/practice/research/medical education:

A literature review was constructed in this contribution to examine the significance of different Paeonia species across the country. As a result of this article, a new understanding of the phytochemistry, traditional medicine, ethnobotany, and potent pharmaceutical properties of the plant is revealed, which may be taken into account in future clinical studies and therapies involving this plant.

Please cite this paper as: Sunil K, Ratha KK, Rao MM, Acharya B. A comprehensive review on the phytochemistry, pharmacological, ethnobotany, and traditional uses of Paeonia species. J Herbmed Pharmacol. 2023;12(1):13-24. doi: 10.34172/ jhp.2023.02.

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Submitted: 10 Jun 2022
Revision: 07 Aug 2022
Accepted: 08 Aug 2022
ePublished: 31 Dec 2022
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